Effects of Derivatives of Hydroxypyruvaldehyde Phenylosazone on Bovine Erythrocyte Membrane. I. Influence on the Osmotic Fragility and Morphology

概要

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Thirteen derivatives of hydroxypyruvaldehyde phenylosazone were tested for effects on bovine erythrocyte membrane. Six drugs, including hydroxypyruvaldehyde phenylosazone itself and the o-CH_3,m-CH_3,p-CH_3,o-Cl and p-Cl derivatives, increased the stability of bovine erythrocyte membrane to hypotonic shock ; the other derivatives with highter molecular weights were essentially without effect. Observations by scanning electron microscopy indicated that non-substituted, m-CH_3 and o-Cl hydroxypyruvaldehyde phenylosazones caused extrusion of the erythrocyte surface, whereas o-CH_3,p-CH_3 and p-Cl derivatives caused invagination of the erythrocyte membrane. The p-Cl derivative can be adsorbed onto, or incorporated into the bovine erythrocyte membrane.
社団法人日本薬学会の論文
1982-03-25