食品添加物と消化酵素作用(第3報) : 着色料とトリプシンその2
スポンサーリンク
概要
- 論文の詳細を見る
Effect of food dyes on the amidase activity of trypsin was examined by using a synthetic substrate, N^α-benzoyl-L-arginine amide. Xanthene dyes strongly inhibited the tryptic activity, as shown previously in the case of hydrolysis of casein. The effects of xanthene dyes including fluorescein and its lower halogenated derivatives were also examined. From the experimental results, it was found that the extent of inhibition becomes stronger in the following order : fluorescein, 2', 7'-dichlorofluorescein<4', 5'-diiodofluorescein, 4', 5'-dibromofluorescein<eosine<3,4,5,6-tetrachlorofluorescein<erythrosine<phloxine<rose bengal. It seems that the extent of inhibition is related to the number and position of halogen atoms on the structure of xanthene analogs. From Lineweaver-Burk's plots, xanthene dyes exhibited non-competitive inhibitions. Ki values of these dyes were 4.7. 0.7,0.4,0.1,and 0.9 mM, respectively, for eosine, erythrosine, phloxine, rose bengal, and 3,4,5,6-tetrachlorofluorescein.
- 公益社団法人日本薬学会の論文
- 1970-06-30
著者
関連論文
- サンドイッチ酸素抗体法による食品中のカラギーナンの測定
- サンドイッチ酵素抗体法によるカラギーナンの測定について
- 薬学生の就職氷河期と企業求人活動の問題点
- ゲル濾過を用いた食品添加物カラギーナン中の単糖, 二糖の定量
- 酵素法による食品中グルコース, フルクトース, ショ糖の同時定量
- アスパラギン結合型糖蛋白質糖鎖の部分合成 (糖質--その反応,合成,機能および利用特集号)
- Synthesis of 2-Acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-deoxy-3-O-(α-L-fucopyranosyl)-D-glucopyranose (3-O-α-L-Fucopyranosyl-di-N-acetylchitobiose)
- Chemical Modification of Lactose. XIII. Synthesis of Lacto-N-tetraose
- A Preparation of the Branched Trisaccharide 2-Acetamido-2-deoxy-4-O-(β-D-galactopyranosyl)-3-O-(β-D-xylopyranosyl)-D-glucopyranose (3-O-β-D-Xylopyranosyl-N-acetyllactosamine)
- Chemical Modification of Lactose. XII. Preparation of O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl)-(1→6)-O-β-D-galactopyranosyl-(1→4)-D-glucopyranose (6´-N-Acetylglucosaminyllactose)
- Synthesis of Methyl O-β-D-Galactopyranosyl-(1→6)-O-α-D-galactopyranosyl-(1→6)-O-α-D-galactopyranosyl-(1→6)-O-β-D-glucopyranoside
- Chemical Modification of Lactose. IX. Synthesis of O-β-D-Galactopyranosyl-(1→6)-O-β-D-galactopyranosyl-(1→4)-D-glucopyranose (6'-Galactosyllactose)
- A Facile Synthetic Approach for Alkyl α-Glycosides of Reducing Disaccharides
- Chemical Modification of Lactose. XIII. Synthesis of Lacto-N-tetraose
- マルチトールのイソプロピリデン化反応とα-グリコシド結合を持つ二糖類の新合成経路
- New Syntheses of 6-Deoxy-L-gulose and 6-Deoxy-L-talose
- Chemical Modification of Maltose. VII. Synthesis of 4-O-(2-Acetamido-2-deoxy-α-D-glucopyranosyl)-D-glucopyranose (GlcNAcα1→4Glc)
- Chemical Modification of Maltose. VI. Selective p-Toluenesulfonylation of 1,6-Anhydro-4', 6'-O-benzylidene-β-maltose using Phase Transfer Catalysis
- Chemical Modification of Maltose. V. A New Synthesis of 2-Acetamido-2-deoxy-4-O-α-D-glucopyranosyl-α-D-glucopyranose (N-Acetylmaltosamine)
- Chemical Modification of Maltose. IV. Synthesis of 4-O-α-D-Altropyranosyl-D-glucopyranose
- Chemical Modification of Maltose. III. Selective p-Toluenesulfonylation of 1,6-Anhydro-4', 6'-O-benzylidene-β-maltose
- Studies on Catalytic Hydrogenation of the Exocyclic Double Bond in Reducing Disaccharides
- 酪酸により各種HeLa細胞において誘導されたアルカリ性ホスファターゼのホスファチジルイノシトール特異的ホスホリパーゼCに対する感受性
- Metal Ion-Activated Acid Adenosine Triphosphatase from Chicken Liver Lysosomes : Purification and Enzyme Properties
- Effects of Derivatives of Hydroxypyruvaldehyde Phenylosazone on the Ca^-Adenosine Triphosphatase Activity of Porcine Erythrocyte Membrane
- Effects of Derivatives of Hydroxypyruvaldehyde Phenylosazone on Bovine Erythrocyte Membrane. I. Influence on the Osmotic Fragility and Morphology
- 糖の科学に魅せられて
- Effects of Derivatives of Hydroxypyruvaldehyde Phenylosazone on Bovine Erythrocyte Membrane. II. Stabilization of Sphingomyelinase C-Treated or Untreated Cells Examined by Coil Planet Centrifugation and Electron Microscopy
- 食品添加物のトリプシンヘの影響カップ法およびディスク法による検討
- オリゴ糖の1,6-アンヒドロ誘導体の^C Nuclear Magnetic Resonanceスペクトル
- ラクト-N-テトラオース誘導体の^C-Nuclear Magnetic Resonanceスペクトル
- Alteration in Reactivity of Sphingomyelinase from Streptomyces sp. Modified with a Polyethylene Glycol Derivative
- Changes in Enzymatic and Membrane-Adsorbing Activities of Sphingomyelinase from Bacillus cereus by Modification with a Polyethylene Glycol Derivative
- The Study on Phosphatidylinositol-Specific Phospholipase C from Bacillus thuringiensis : Synthesis of Homogeneous Substrates, Substrate Specificity and Other Properties
- Syntheses of Acetylated Trisaccharides, Manα1→3Manβ1→4GlcNAc and Manα1→2Manβ1→4GlcNAc, relating to Mannosidosis
- 環状ホスファチジン酸の高等動物での存在と生合成
- マウス・ミ***ーマ細胞NS-1より抽出したリン脂質のESI-MS/MSによる構造解析
- ホスファチジルイノシトール・アンカー蛋白質の加水分解におけるmyo-イノシトールの異性化によるchiro-イノシトールの生成
- マウスNS-1細胞におけるリン脂質及びグリコシルP1のES1-MSによる分析
- The Effects of Coexising Lipids on the Action of Bacillus thuringiensis Phosphatidylinositol-Specific Phospholipase C toward Liposomal Substrate
- Action of Phosphatidylinostiol-Specific Phospholipase C from Bacillus thuringiensis is Significantly Influenced by Coexisting Lipids in Substrate-Detergent Micelles
- Phospholipase D Modified with a Polyethylene Glycol Derivative
- 試薬としての酵素(脂質編)--ホスホリパ-ゼC
- Studies on the Interactions between Phospholipids and Membrane-Bound Enzymes in Microsomes. Effects of Phosphatidylinositol-Specific Phospholipase C on Enzymes of Rat Liver Microsomes
- オクテット
- Syntheses of Acetylated Tetrasaccharides, Manα1→2Manα1→3Manβ1→4GlcNAc and Manα1→3Manα1→6Manβ1→4GlcNAc
- 乳糖の反応および人乳オリゴ糖と類似体合成の試み
- Syntheses of 2-Acetamido-2-deoxy-4-O-β-D-galactopyranosyl-D-glucopyranose (N-Acetyllactosamine) Derivatives
- Chemical Modification of Lactose. XVII. Syntheses of O-α- and O-β-L-Fucopyranosyl-(1→4)- or -(1→6)-O-β-D-galactopyranosyl-(1→4)-D-glucopyranoses (4'- or 6'-O-α- and -O-β-L-Fucopyranosyllactoses)
- Synthesis of 2-Acetamido-1,6-anhydro-3-O-benzyl-2-deoxy-β-D-glucopyranose, a Useful Glycosyl Acceptor for 1,4-Linked, N-Acetylglucosaminecontaining Oligosaccharides Synthesis
- オリゴ糖-L-アスパラギン化合物の合成 (糖質の化学)
- 糖タンパク質の糖鎖部の有機合成
- Chemical Modification of Lactose. XVI. : Synthesis of Lacto-N-neohexaose
- Chemical Modification of Lactose. XV. Syntheses of O-α- and O-β-L-Fucopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→4)-D-glucopyranoses (3'-O-α- and 3'-O-β-L-Fucopyranosyllactoses)
- Chemical Modification of Lactose. XIV. Synthesis of O-2-Acetamido-2-deoxy-β-D-glucopyranosyl-(1→3)-O-[2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)]-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranose (3', 6'-Di-β-N-acetylglucosaminyl-β-lactose)
- Chemical Modification of Lactose. XVI. Synthesis of Lacto-N-neohexaose
- Chemical Modification of Lactose. XI. A New Synthesis of 2-Acetamido-2-deoxy-4-O-β-D-galactopyranosyl-α-D-glucopyranose (N-Acetyllactosamine)
- Chemical Modification of Lactose. VIII. Studies on the Reactivities of the Secondary Hydroxyl Groups in 1,6-Anhydro-4', 6'-O-benzylidene-β-lactose by Selective p-Toluenesulfonylation
- 食品添加物と消化酵素作用(第4報) : 着色料とトリプシンその3
- 食品添加物と消化酵素作用(第3報) : 着色料とトリプシンその2
- 食品添加物と消化酵素作用(第2報) : 着色料とトリプシンその1
- 食品添加物と消化酵素作用(第1報) : 保存料とトリプシン
- GPIアンカータンパク質の分子生物学
- 古細菌Sulfolobus acidocaldariusに存在するGPIアンカー蛋白質
- A New Synthesis of α-L-Fucose
- Chemical Modification of Lactose. X. Syntheses of 4-O-(3-O-Methyl-β-D-idopyranosyl)-D-glucopyranose and 4-O-(3-Deoxy-β-D-lyxo-hexopyranosyl)-D-glucopyranose
- Chemical Modification of Lactose. VII. Synthesis of 4-O-β-D-Idopyranosyl-D-glucopyranose
- Chemical Modification of Lactose. VII. Synthesis of 4-0-β-D-Idopyranosyl-D-glucopyranose
- ホスファチジルイノシト-ルホスホリパ-ゼC(PI-specific PLase C)の作用による膜結合タンパク質の遊離--いわゆるPI-anchoring proteinの新しい登場
- 食物繊維定量法の検討 : Neutral Detergent法と酵素-重量法について
- アスパラギン結合型糖蛋白質糖鎖の部分合成
- GPIアンカー蛋白質 (脂質共有結合による蛋白質機能調節)
- 細菌のPI特異的Phospholipase C(PIPLC)の生理作用およびGPIアンカ-膜タンパク質研究への応用
- PIアンカ-型膜蛋白質の生化学
- ホスファチジルイノシト-ルホスホリパ-ゼCによる細胞膜結合酵素の遊離
- Chlorella vulgaris成分の利用研究(第5報) : 藻体外に分泌されたCarbohydraseについてその2
- 薬学会総会は何故必要か : 肯定的立場から(薬学会の総会・分科会制度の是非)
- 細菌のPI特異的Phospholipase C (PIPLC)の生理作用およびGPIアンカー膜タンパク質研究への応用
- 教養部とじゅうぶん話合いたい(薬学生の一般教育をより意義あるものにするためには)
- 糖の化学をめぐる30年