Syntheses of Acetylated Tetrasaccharides, Manα1→2Manα1→3Manβ1→4GlcNAc and Manα1→3Manα1→6Manβ1→4GlcNAc
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概要
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As a preliminary experiment aimed ultimately at the total syntheses of high mannose-type oligosaccharides in glycoproteins, two fully acetylated tetrasaccharides, Manα1→2Manα1→3Manβ1→4GlcNAc (32) and Manα1→3Manα1→6Manβ1→4GlcNAc (35), were synthesized by block condensation of acetylated dimannopyranosyl bromides with suitably protected Manβ1→4GlcNAc derivatives by modified Koenigs-Knorr reactions, followed by acetylation of the deprotected tetrasaccharides. Proton and carbon-13 nuclear magnetic resonance spectral data for 32,35,and synthetic intermediates are also presented. The present work confirms that 1,6-anhydro-β-derivatives of GlcNAc and oligosaccharides are versatile starting materials or key intermediates for syntheses of complex oligosaccharides.
- 公益社団法人日本薬学会の論文
- 1984-03-25
著者
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手島 節三
名古屋市立大学薬学部
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手島 節三
Faculty of Pharmaceutical Sciences, Nagoya City University
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手島 節三
Faculty Of Pharmaceutical Sciences Nagoya City University
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伊藤 嘉雄
Faculty Of Pharmaceutical Sciences Nagoya City University
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