Thiosugars. XVI. Synthesis of Cellobiose Derivatives having Sulfur Atom in the Reducing Moiety
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概要
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A facile synthesis of cellobiosan hexaacetate (II) was described. Zemplen degradation of II, followed by the Koenigs-Knorr reaction was shown to yield 1,2,3,2', 3', 4', 6'-hepta-Oacetyl-β-cellobiose (III) in 45% yield. Crystalline 6-methylsulfonate (IV), p-tolylsulfonate (V), and 6-deoxy-6-iodo acetate (VI) were synthesized. Starting from IV, via the crystalline ethylxanthate (VIII), 1,6-anhydro-6-thio-β-cellobiose (6-thiocellobiosan) (XIII) and the fully acetate (XII) were synthesized. Five fully acetylated cellobiose derivatives (VII, IX, X, XI, and XIV) having sulfur atom at C_1,C_6,or both of the positions were also synthesized starting from octaacetyl-β-cellobiose, IV, or XII.
- 社団法人日本薬学会の論文
- 1972-09-25
著者
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手島 節三
Faculty of Pharmaceutical Sciences, Nagoya City University
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手島 節三
Faculty Of Pharmaceutical Sciences Nagoya City University
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岡森 克充
Faculty of Pharmaceutical Sciences, Nagoya City University
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岡森 克充
Faculty Of Pharmaceutical Sciences Nagoya City University
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