Synthesis of 2-Acetamido-1,6-anhydro-3-O-benzyl-2-deoxy-β-D-glucopyranose, a Useful Glycosyl Acceptor for 1,4-Linked, N-Acetylglucosaminecontaining Oligosaccharides Synthesis

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概要

• 論文の詳細を見る

• A facile synthesis of the title compound (9) was achieved. Tritylation of 1,6-anhydro-β-N-acetylglucosamine (4) with 3 molar equivalents of trityl chloride in pyridine at 85-90℃ for 24 h afforded the corresponding 4-O-trityl ether (5) and 3-O-trityl ether (6) in 66.9 and 8.3% yields, respectively, after column chromatography. Benzylation of 5 followed by detritylation provided 9 via 3 steps from 4 in ca. 47% yield. Preparation of 2-acetamido-1,6-anhydro-4-O-benzyl-2-deoxy-β-D-glucopyranose (10) from 6 was also carried out.

• 公益社団法人日本薬学会の論文
• 1982-09-25

著者

• 手島 節三

  名古屋市立大学薬学部

• 手島 節三

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 手島 節三

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 伊藤 嘉雄

  Faculty Of Pharmaceutical Sciences Nagoya City University

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