Chemical Modification of Lactose. XVI. Synthesis of Lacto-N-neohexaose

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概要

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• Reaction of 1,6-anhydro-2,2', 3,4'-tetra-O-benzyl-β-lactose (1 mol eq.) with the acetylated oxazoline of N-acetyllactosamine (5 mol eq.) gave the corresponding 1,6-anhydro-β-tetrasaccharide (3,24.5%) and hexasaccharides (8,53.5%). The protecting groups of 3 and 8 were removed by the following series of reactions to provide 6'-N-acetyl-lactosaminyllactose (7) and lacto-N-neohexaose (12), respectively : debenzylation followed by acetylation, acetolysis, and de-O-acetylation. ^<13>C-NMR spectral data for 1,6-anhydro-β-derivatives of 7 and 12 are presented.

• 公益社団法人日本薬学会の論文
• 1981-02-25

著者

• 手島 節三

  名古屋市立大学薬学部

• 手島 節三

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 高村 吏

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 千葉 拓

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 手島 節三

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 高村 吏

  Research And Development Division General Laboratory Arakawa Chotaro & Co.

• 千葉 拓

  名古屋市立大学薬学部

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