Syntheses and Antitumor Activities of N^6,N^6-Dimethyladenosine Carboxylate Analogues
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概要
- 論文の詳細を見る
Several analogues substituted with fatty acid at the 2'-, 3'-, or 5'-position of the ribose moiety of N^6,N^6-dimethyladenosine were synthesized and tested for antitumor activity against cultured cells of L1210 leukemia and/or Ehrlich ascites. The cytotoxity and increase of life span obtained with congeners in the N^6,N^6-dimethyladenosine 3'- or 5'-substituted series were comparable to in vitro or several times better in vivo than those of the mother compound.
- 公益社団法人日本薬学会の論文
- 1989-10-25
著者
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高村 吏
Research And Development Division General Laboratory Arakawa Chotaro & Co.
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加藤 哲夫
株式会社アラクス研究開発部
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加藤 哲夫
Research and Development Division, General Laboratory, Arakawa Chotaro & Co.,
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荒川 永太郎
Research and Development Division, General Laboratory, Arakawa Chotaro & Co.,
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小川 秀一
Research and Development Division, General Laboratory, Arakawa Chotaro & Co.,
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鈴村 恭子
Laboratory of Chemotherapy, Aichi Cancer Center Research Institute
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加藤 武俊
Laboratory of Chemotherapy, Aichi Cancer Center Research Institute
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小川 秀一
Research And Development Division General Laboratory Arakawa Chotaro & Co.
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加藤 武俊
Laboratory Of Chemotherapy Aichi Cancer Center Research Institute
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鈴村 恭子
Laboratory Of Chemotherapy Aichi Cancer Center Research Institute
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荒川 永太郎
Research And Development Division General Laboratory Arakawa Chotaro & Co.
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