Interaction of Parabens and Other Pharmaceutical Adjuvants with Plastic Containers
スポンサーリンク
概要
- 論文の詳細を見る
The possible interaction has been studied between plastics and several drugs and pharmaceutical adjuvants such as parabens, quaternary ammonium salts, and HCO-50 (polyoxyethylene derivative of hydrogenated castor oil). It was found that hydrophobic interaction plays a major role in adsorption of parabens to several plastics studied. Studies on the effect of temperature on adsorption and desorption suggest that the drug-binding sites of plastics may be hidden in the structure at low temperature and unfolded to the surface by configuration change at high temperature. HCO-50 was non-selectively adsorbed to all plastics studied and maximum adsorption occured near the region of the critical micelle concentration of HCO-50.
- 社団法人日本薬学会の論文
- 1971-12-25
著者
-
荒川 永太郎
Faculty of Pharmaceutical Sciences, Kyoto University
-
池田 桂子
Research Laboratory Morishita Pharmaceutical Co. Ltd.
-
瀬崎 仁
Faculty Of Pharmaceutical Sciences Kyoto University
-
排見 喜一郎
Faculty of Pharmaceutical Sciences, Kyoto University
-
木村 和子
Faculty of Pharmaceutical Sciences, Kyoto University
-
木村 和子
Faculty Of Pharmaceutical Sciences Kyoto University
-
荒川 永太郎
Research And Development Division General Laboratory Arakawa Chotaro & Co.
-
排見 喜一郎
Faculty Of Pharmaceutical Sciences Kyoto University
関連論文
- Lymphatic Transport of Griseofulvin in the Rat and the Possible Factors Determining the Extent of Lymphatic Absorption
- The Significance of Vehicle Oil Metabolism in the Absorption Process of Lipid-Soluble Compounds
- Regional Capacities of Gastrointestinal Absorption and Lymphatic Transport for Lipid-Soluble Dyes in Rats
- Studies on Pharmaceutical Modification of Anticancer Agents. I. Enhancement of Lymphatic Transport of Mitomycin C by Parenteral Emulsions
- Mechanism of the Intestinal Absorption of Drugs from Oil-in-Water Emulsions. VII. Role of Bile in the Lymphatic Transport of Lipid-Soluble Compounds from Triolein Emulsions
- Mechanism of the Intestinal Absorption of Drugs from Oil-in-Water Emulsions. VI. Absorption of Lipid-Soluble Dyes from Tributyrin and Triolein Emulsions in Rat Small Intestine
- Effect of Short-Chain Fatty Acids on the Intestinal Absorption of Drugs in the Rat
- Studies on the Stability of Drugs in Biological Media. III. Effect of Cupric Ion on the Stability and Antibacterial Activity of Penicillins in Culture Medium
- Effects of Perfusate Constituents on Transmucosal Fluid Movement and Drug Absorption in Rat Small Intestine
- The Use of Liposomes as Enzyme Carriers. I. Dependence of Enzyme Stability on the Method of Preparation
- Potential Absorption of Heparin from the Small Intestine and the Large Intestine in the Presence of Monoolein Mixed Micelles
- AN ASSESSMENT OF GASTROINTESTINAL MUCOSAL DAMAGE IN VIVO : ENHANCEMENT OF URINARY RECOVERY AFTER ORAL ADMINISTRATION OF PHENOLSULFONPHTHALEIN IN ULCER RATS
- Dosage Form Characteristics of Microsphere-in-Oil Emulsion. II : Examination of Some Factors Affecting Lymphotropicity
- Effects of Various Absorption Promoters on Pulmonary Absorption of Drugs with Different Molecular Weights
- Assessment of Pharmaceutical Excipient-Induced Gastrointestinal Mucosal Damage in Rats in Vivo by Measuring the Permeation of Phenolsulfonphthalein
- Application of Liposomes to the Pharmaceutical Modification of the Distribution Characteristics of Drugs in the Rat
- Application of Drug-Containing Liposomes to the Duration of the Intramuscular Absorption of Water-Soluble Drugs in Rats
- Effect of Some Ionic and Nonionic Surfactants on the Intramuscular Absorption of Isonicotinamide
- Intramuscular Absorption of Drugs from Oily Solutions in the Rat
- Absorption of Drugs from the Skeletal Muscle of the Rats. V. Effect of Potassium Ion on the Absorption of Some Anionic Drugs
- Absorption of Drugs from the skeletal Muscle of the Rats. (4) Absorption of Cationic Drugs from the Muscle
- Absorption of Drugs from the Skeletal Muscle of the Rats. (3). Effect of Watersoluble Adjuvants and Vehicles on the Intramuscular Absorption
- Absorption of Drugs from the Skeletal Muscle of the Rats. (2)
- Absorption and Excretion of Drugs. XXXIX. The Absorption of Isonicotinic Acid Derivatives from the Skeletal Muscle of the Rats
- Studies on the Pharmaceutical Potentiation of Drugs. N. Biopharmaceutical Study on the Derivatives of p-Aminosalicylic Acid.
- Interaction of Parabens and Other Pharmaceutical Adjuvants with Plastic Containers
- Effect of 5-n-Butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine on the Sulfonamides Transfer in the Rat
- Percutaneous Absorption of Butylparaben from Liposomes in Vitro
- Preservative Activity and in Vivo Percutaneous Penetration of Butylparaben Entrapped in Liposomes
- Studies on Pharmaceutical Modification of Anticancer Agents. II. Enhanced Delivery of Bleomycin into Lymph by Emulsions and Drying Emulsions
- Intestinal Absorption Aspect of Non-lipophilic Low Molecular Weight Drugs : A Case of Cephalexin and Cefazolin
- Role of Membrane Components, Glycocalyx and Lipid in Absorption of Water-soluble Dyes from the Rat Small Intestine
- Mechanisms of the Absorption of Water-soluble Dyes from the Rat Small Intestine
- Plasma Disposition and in Vivo and in Vitro Antitumor Activities of Mitomycin C-Dextran Conjugate in Relation to the Mode of Action
- Segmental Difference in Transmucosal Fluid Movement and Glucose Effect on Drug Absorption from Rat Gastrointestinal Tract
- Transmucosal Fluid Movement and Its Effect on Drug Absorption
- Hydrolysis of Acetylsalicylsalicylic Acid and Salicylsalicylic Acid in Aqueous Solution
- Role of Intestinal Mucus in the Absorption of Quinine and Water-soluble Dyes from the Rat Small Intestine
- Further Studies on the Mechanism of the Absorption of Ion Pair Complex from the Rat Small Intestine
- The Transport of a Drug to the Cerebrospinal Fluid Directly from the Nasal Cavity : The Relation to the Lipophilicity of the Drug
- Drug-induced Histological Changes and Its Consequences on the Permeability of the Small Intestinal Mucosa. II
- Drug-induced Histological Changes and Its Consequences on the Permeability of the Small Intestinal Mucosa. I. EDTA, Tetracycline, and Sodiun Laurylsulfate
- Regeneration Characteristics of Mitomycin C-Dextran Conjugate in Relation to Its Activity
- Syntheses and Antitumor Activities of N^6,N^6-Dimethyladenosine Carboxylate Analogues
- General Base Catalyzed Hydrolysis of Furylmethylketone Isonicotinoylhydrazone
- Studies on the Stability of Drugs in Biological Media. (2). Relationship between the Stability in Culture Media and Anti-bacterial Activity of Some Isoniazid Derivatives
- Studies on the Stability of Drugs in Biological Media. (1). Stability of Furylmethylketone Isonicotinoylhydrazone in Culture Media
- Effect of Various Alcohols on the Intramuscular Absorption of Isonicotinamide in the Rat
- Effect of Ethanol on the Intramuscular Absorption of Water-soluble Drugs in the Rat
- Effect of Complex Formation on the Intestinal Absorption of Tryptophan
- Studies on Molecular Interaction of Organic Molecules in Solution. I. Effects of Solvent on Molecular Interaction of Salicylic Acid with Caffeine
- Effect of Conformation of Molecules on Molecular Interaction. II. Nicotinamides and Pyridine Esters
- Inhibitory Mechanism of Imipramine on Barbiturate Metabolism in Rat Liver
- Effect of Bile Salts on the Gastrointestinal Absorption of Drugs. II. Mechanism of the Enhancement of the Intestinal Absorption of Sulfaguanidine by Bile Salts
- Enhancement of Membrane Permeability to a Poorly Absorbed Drug by Medium-Chain GLycerides : Effect of Medium-Chain Glycerides on the Release of Phenol Red from Egg Phosphatidylcholine Liposomes
- Intestinal Absorption of Drugs from Solubilized Systems of Long-Chain Fatty Acids in the Rat
- Blood Dispositions of Mitomycin C and a Lipophilic Prodrug after Intramuscular and Intravenous Administration in Liposomes and O/W Emulsion
- Effect of Mucosal Lipid Components on the Membrane Permeation of Water-Soluble Drugs
- Development of Lipophilic Prodrugs of Mitomycin C. III. Physicochemical and Biological Properties of Newly Synthesized Alkoxycarbonyl Derivatives
- Physico-chemical and Antitumor Characteristics of High Molecular Weight Prodrugs of Mitomycin C
- More Clarifications concerned with the Photodynamic Action of Riboflavine on the Intestinal Absorption of Drugs in the Rat
- Further Investigations of the Effect of Riboflavine Photolysates on the Intestinal Absorption of Certain Drugs in Rats and Their Mechanism of Action
- Effect of Bile Salts on the Gastrointestinal Absorption of Drugs. IV. Site of Intestinal Absorption of Sodium Taurocholate and Its Consequence on Drug Absorption in the Rat
- Studies on Compounds Related to Antitumor Agents. Syntheses of 8-Substituted N^6,N^6-Dimethyladenosine Derivatives
- Mechanism of the Inhibitory Effect of Surfactants on Intramuscular Absorption of Drugs. (3)
- Mechanism of the Inhibitory Effect of Polysorbate 80 on Intramuscular Absorption of Drugs. (2)
- Mechanism of the Inhibitory Effect of Polysorbate 80 on Intramuscular Absorption of Drugs. (1)
- Effect of Some Cationic Drugs on the Intestinal Absorption of Pralidoxime Iodide
- Characterization of a Lipophilic Prodrug of 5-Fluorouracil with a Cholesterol Promoiety and Its Application to Liposomes
- Mechanism of Drug Absorption from Micellar Solution. II. Effect of Polysorbate 80 on the Absorption of Micelle-free Drugs
- Mechanism of Transfer of Bleomycin into Lymphatics by Bifunctional Delivery System via Lumen of Small Intestine
- Mechanism of the Intestinal Absorption of Drugs from Oil in Water Emulsions. V. Enhanced Absorption of Methyl Orange Adsorbed at Oil/Water Interface in Emulsions
- Mechanism of the Intestinal Absorption of Drugs from Oil in Water Emulsions. IV. Absorption from Emulsions containing the Higher Concentration of Emulsifier
- Mechanism of the Intestinal Absorption of Drugs from Oil in Water Emulsions. III. Absorption and Biotransformation of Methyl Orange
- Mechanism of Intestinal Absorption of Drugs from Oil in Water Emulsions. II. Absorption from Oily Solutions
- Mechanism of Intestinal Absorption of Drugs from Oil in Water Emulsions. I
- Analysis of Skin Penetration Enhancement Based on a Two-Layer Skin Diffusion Model with Polar and Nonpolar Routes in the Stratum Cornuem : Dose-Dependent Effect of 1-Geranylazacycloheptan-2-one on Drugs with Different Lipophilicities
- Hydrolytic and Associative Behavior of Aromatic Amides in Aqueous Solution
- Biochemical and Biopharmaceutical Properties of Macromolecular Conjugates of Uricase with Dextran and Polyethylene Glycol
- Fate of Lipid and Encapsulated Drug after Intramuscular Administration of Liposomes Prepared by the Freeze-Thawing Method in Rats
- Effect of 1-Alkyl- or 1-Alkenylazacycloalkanone Derivatives on Penetration of Mitomycin C through Rat Skin(Pharmaceutical,Chemical)
- Absorption Characteristics of Macromolecular Prodrugs of Mitomycin C Following Intramuscular Administration
- Timed-Release of Mitomycin C from Its Agarose Bead Conjugate
- Prolonged Release of Bleomycin from Parenteral Gelatin Sphere-in-Oil-in-Water Multiple Emulsion
- Dosage Form Characteristics of Microsphere-in-oil Emulsions. I : Stability and Drug Release
- Absorption and Excretion of Drugs. XXIX. Effect of Surface-active Agents on Rectal Absorption of Sulfisoxazole from Oily Base
- Antitumor Activity of Timed-release Derivative of Mitomycin C, Agarose Bead Conjugate
- Mechanism of Drug Absorption from Micellar Solution. I. Absorption of Solubilized Vitamin A from the Rat Intestine
- Studies on the Factors Affecting Pulmonary Absorption of Xanthine Derivatives in the Rat(Pharmaceutical)
- Evaluation of Water in Oil and Microsphere in Oil Emulsions as a Specific Delivery System of 5-Fluorouracil into Lymphatics
- Absorption and Excretion of Drugs. XXII. Absorption of Isoniazid and its Derivatives
- Studies on the Pharmaceutical Potentiation of Drugs. III. Antagonistic Effects of PABA on Antitubercular Activities of PAS Derivatives.
- Studies on Molecular Interaction in Solution. I. Effects of Organic Ions on the Solubility of 8-Methoxycaffeine
- fasting and the Volume of Drug Distribution in the Rats
- Effect of Fasting and Antineoplastic Agents on the Intestinal Absorption of Drugs in the Rats
- Absorption and Excretion of Drugs. XLI. Studies on the Gastrointestinal Absorption of 2-Pyridine Aldoxime Methiodide and Its Derivatives.
- Absorption and Excretion of Drugs. XL. Enhancement of the Rectal Absorption of Pharmaceutical Amines with Lauryl Sulfate and Saccharinate Anions