Effects of Perfusate Constituents on Transmucosal Fluid Movement and Drug Absorption in Rat Small Intestine

概要

論文の詳細を見る
Effects of various constituents of the perfusates on the sulfanilamide absorption were investigated using in situ recirculation perfusion method with the rat small intestine. Constituents employed were salts and chemical which had been used as components in various buffer solutions and these salts were used in a single or in combination with each other. The results revealed that both of the absorption and the transmucosal fluid movement were considerablly influenced by the constituents of the perfusates. Some salts exhibited lethal effects during the course of the experiment. These results were not able to rule out by pH of the perfusates. However, it was found out that these results had one regression line which was the same as that obtained from the perfusates containing different concentrations of sodium chloride. Taking these lines of evidences into accounts, the protocol in the determining the absorption using the in situ recirculation perfusion technique was proposed and discussed.
社団法人日本薬学会の論文
1976-12-25