Hydrolysis of Acetylsalicylsalicylic Acid and Salicylsalicylic Acid in Aqueous Solution
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概要
- 論文の詳細を見る
The hydrolysis of acetylsalicylsalicylic acid and salicylsalicylic acid in aqueous solutions of ionic strength 0.5 were investigated at various pH by means of a high performance liquid chromatographic method. The degradation of acetylsalicylsalicylic acid is considered to be a complex reaction in which parallel and consecutive reactions are involved ; that is, acetylsalicylsalicylic acid may degrade through two pathways to form acetylsalicylic acid and salicylsalicylic acid, and subsequently, both compounds may be converted to salicylic acid. The overall degradation of acetylsalicylsalicylic acid obeyed pseudo-first-order kinetics. The pH-rate profiles for the reactions were determined by monitoring the degradation products.
- 公益社団法人日本薬学会の論文
- 1985-05-25
著者
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砂田 久一
Faculty Of Pharmacy Meijo University
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大塚 昭信
Faculty of Pharmacy, Meijo University
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原 克巳
Faculty Of Pharmacy Meijo University
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伊庭 克英
Chemical Research and Development Division, General Laboratories, Arakawa-Chotaro & Co.
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小川 秀一
Chemical Research and Development Division, General Laboratories, Arakawa-Chotaro & Co.
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荒川 永太郎
Chemical Research and Development Division, General Laboratories, Arakawa-Chotaro & Co.
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増山 哲子
Faculty of Pharmacy, Meijo University
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小川 秀一
Research And Development Division General Laboratory Arakawa Chotaro & Co.
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大塚 昭信
Faculty Of Pharmacy Meijo University
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増山 哲子
Faculty Of Pharmacy Meijo University
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伊庭 克英
Chemical Research And Development Division General Laboratories Arakawa-chotaro & Co.
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荒川 永太郎
Research And Development Division General Laboratory Arakawa Chotaro & Co.
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