Influence of Moisture Adsorption of Volume Shrinkage and Diametral Tensile Strength of Sucrose Tablets
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概要
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Changes in the size and tensile strength of tablets were investigated after storage at several levels of relative humidity (R.H.). Sucrose has a critical relative humidity (CRH) of 84.0%. The diameter and thickness of the tablets decreased with storage at increasing R.H., and then suddnely increased above the CRH. The relationship between the rates of the volume change and moisture adsorption was linear (R^2=0.963).The diametral tensile strength increased with storage at 84% R.H., above which it decreased. This was due to the increase in the radii of curvature of the water films and smoothing of the particulate surface by dissolution of surface asperities. It was therefore assumed that slippage and transfer of particles easily occurs between contacting surfaces.Diametral tensile strength increased with increasing water evaporation.
- 1993-12-15
著者
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大塚 昭信
名城大学
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大塚 昭信
Faculty of Pharmacy, Meijo University
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壇上 和美
Faculty of Pharmacy, Meijo University
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脇本 彪
Toa Pharmaceutical Industrial Co. Ltd.
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加藤 博信
Faculty of Pharmacy, Meijo University
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大塚 昭信
Faculty Of Pharmacy Meijo University
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加藤 博信
Pharmacy Laboratories R & D Division Nippon Shinyaku Co. Ltd.
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