Effect of Binder Characteristics on the Strength of Agglomerates Prepared by the Wet Method

概要

論文の詳細を見る
The effect of the physicochemical properties of binders on the strength of agglomerates prepared by the wet method was investigated using untreated and surface trimethylsilylated glass beads as model powders. The crushing test of granules and the bending test of molded tablets were carried out in order to estimate the strength of the agglomerates. A quantitative approach based on the work of Rumpf et al. was attempted to obtain the strengths between two contacting particles. The calculated values were in fair agreement with those obtained by the separation test using two big balls. In all the systems, the agglomerates prepared from surface treated glass were weaker in strength than those from untreated glass. In conclusion, it was apparent that the strength of an agglomerate was related both to the wetting of a particle by a binder solution and to the binder cohesion.
社団法人日本薬学会の論文
1993-08-15