Effect of Granule Strength on Compressed Tablet Strength
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概要
- 論文の詳細を見る
The effect of granule strength on the strength of a tablet compressed under a certain force was examined. Crushing strength and diametral compression tests were carried out to assess granule and tablet strength, respectively. When granules were weak, tablet strength increased with granule strength. In some powder/polymer binder systems, a further increase in granule strength led to tablets with maximal strength, which then decreased. It was apparent that hard granules were difficult to deform by compression, and the resulting tablets fractured at the boundary between granules.
- 社団法人日本薬学会の論文
- 1995-12-15
著者
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壇上 和美
名城大学薬学部製剤学研究室
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大塚 昭信
名城大学
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堀沢 栄次郎
マルホ株式会社京都r&dセンター創剤技術研究所
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堀沢 栄次郎
Hikone Research Laboratories, Maruho Co., Ltd.,
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小村 昭夫
Hikone Research Laboratories, Maruho Co., Ltd.,
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檀上 和美
Faculty of Pharmacy, Meijo University
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大塚 昭信
Faculty of Pharmacy, Meijo University
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小村 昭夫
マルホ(株)研究部
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Danjo K
名城大学 薬学部
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壇上 和美
名城大学薬学部製剤学教室
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Danjo K
Fac. Of Pharmacy Meijo Univ.
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大塚 昭信
Faculty Of Pharmacy Meijo University
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檀上 和美
Faculty Of Pharmacy Meijo University
-
堀沢 栄次郎
Hikone Research Laboratories Maruho Co. Ltd.
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小村 昭夫
Hikone Research Laboratories Maruho Co. Ltd.
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