Pharmaceutical Preparations of Crude Drug Powder. III.The Effects of the Physical Properties of the Binder Solution on the Characteristics of the Granule from the Mixed Powders

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The granulation from mixed crude drug powders was carried out by fluidized bed and agitation methods. The effects of the physical properties of the binder solution, such as the contact angle on the powder compact, the viscosity, on the granule characteristics, the average granule size, angle of repose, bulk density, granule strength, compressibility, and strength of compact, were examined.Correlation between the physical properties of the products obtained by fluidized bed granulation and agitation granulation, and those of the binder solution were analysed by using the correlation formula derived from multiple regression analysis. A highly confident multiple correlation was found and the relationship between physical properties of the binder solution and those of the granules can be expressed quantitatively.It suggests the possibility that formulation of powder materials for production of granules having desirable physical properties can be easily determined and, also, the granulating manipulation which has been performed experimentally or qualitatively, can be done quantitatively and rationally, by using the results.
公益社団法人日本薬学会の論文
1993-05-15