2-ヒドロキシアゾメチン誘導体のアルミニウムキレートのけい光強度に対するFree-Wilsonの解析法の適用

概要

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Several 2-hydroxyazomethines having various substituent groups were prepared and the effect of the substituent groups on the fluorescence intensity of aluminum chelates of these compounds was investigated by the use of Free-Wilson's method, which has been known as a methematical technique describing structurebiological activity relationships of a series of chemical analogs. The mathematical model used is based upon the assumption that the fluorescence intensity in a series of analog can be given as the sum of the "over-all average" values and the contribution of each substituent. For the testing compounds successful solutions of the equations based on the model were obtained. So it became obvious that this method could be applicable to the studies of fluorescence intensity-structure relationships as well as structure-biological activity relationships.
社団法人日本分析化学会の論文
1979-03-05