中小病院における院内製剤の品質評価 : プロゲステロン膣坐剤

概要

論文の詳細を見る
Progesterone (P) is an important hormone for achieving pregnancy, and administering it is a useful therapy for luteal insufficiency. However, owing to problems with existing oral preparations and injections, P is increasingly administered by the transvaginal route in suppository form in medical institutions. Since vaginal suppositories are not commercially available, each institution has to prepare its own. For P-containing vaginal suppositories prepared in our hospital, we conducted hardness, weight variation, content uniformity, and elution tests as well as a 6-month stability test in cold storage and pharamacodynamics testing in vivo. The results confirmed that they were uniform in quality and stable, and valid for use as pharmaceutical preparations in clinical practice. Furthermore, the sustained-release suppositories prepared by us were found to maintain adequate blood levels of P.
日本医療薬学会の論文
2005-10-10