Changes of Surface Area in the Dissolution Process of Crystalline Substances. V. : Dissolution and Simulation Curves for Log-Normal Particle-Size-Distributed Model Systems

概要

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The dissolution of log-normal particle-size-distributed model systems prepared with sieved n-propyl p-hydeoxybenzoate crystalline particles was conducted under the silk condition. The log-normal particle-size distributed systems were expressed as a generalized equation and distribution curve, and mixed systems were prepared following the generalized distribution curves. The dissolution of the mixed systems, composed of particles whose chenges of surface area during the dissolution were not easy to measure, was carried out under the silk condition. These dissolution processes were simulated by the use of the relationship between the surface-producing rate constant and the initial particle size deduced with some components. The simulated values for the dissolution showed fairly good coincidence with those measured, and it is considered that the relationship between the surface-producing rate constant and the initial particle size is useful for prediction of the dissolution behavior of mixed systems.
公益社団法人日本薬学会の論文
1990-04-25