Caking of δ-D-Gluconolactone Powder
スポンサーリンク
概要
- 論文の詳細を見る
The sorption of water vapor and the caking behavior of δ-D-gluconolactone (DGL) have been studied. Severe caking of DGL was observed only when both the humidifying and the subsequent drying procedure were taken on it. The crushing strength of the cake increased with an increase in the amount of water evaporated in the drying process. These results may prove the conception that caking is mainly caused by solid bridges formed by the crystallization of dissolved DGL. The caking of DGL was influenced by the compaction state of powder beds. The crushing strength showed a trend to increase with decreasing porosity. It may be due to the increase in the number of total contact points between powder particles.
- 公益社団法人日本薬学会の論文
- 1975-03-25
著者
-
壇上 和美
名城大学薬学部製剤学研究室
-
砂田 久一
Faculty Of Pharmacy Meijo University
-
檀上 和美
Faculty of Pharmacy, Meijo University
-
Danjo K
名城大学 薬学部
-
壇上 和美
名城大学薬学部製剤学教室
-
塩路 雄作
Fujisawa Pharmaceutical Co., Ltd.
-
塩路 雄作
Fujisawa Pharmaceutical Co. Ltd.
関連論文
- 微粒子吸入による高分子薬物の全身及び肺局所送達(誌上シンポジウム)
- Effect of Granule Strength on Compressed Tablet Strength
- Effect of Binder Characteristics on the Strength of Agglomerates Prepared by the Wet Method II
- Effect of Binder Characteristics on the Strength of Agglomerates Prepared by the Wet Method
- Computer Simulation of Agglomeration by a Two-Dimensional Random Addition Model. IV. : Agglomeration Kinetics and Micromeritic Properties of Agglomerate of Binary Mixtures of Adhesive Circles
- 粉粒体の圧縮性と応力緩和におよぼす圧縮速度の影響
- Flocculation Kinetics of the Monodisperse System. II. Computer Simulation of Flocculation with Compaction by the Two-Dimensional Geometrical Random Coalescence Model
- 粉体粒子の充てん性と付着凝集性に対する湿度の影響
- 粉体の充填に関する研究(第2報) : 沈積層単位断面積あたりの球形粒子の平均数と空隙率との関係について
- 生薬粉末の製剤化 : 流動層造粒法による生薬顆粒より製した生薬錠剤について
- 生薬粉末の製剤化 : 流動層造粒法による生薬の顆粒化について
- 生薬粉末の製剤化 : ローラーコンパクターを用いた乾式造粒法について
- Effect of Several Cellulosic Binders on Particle Size Distribution in Fluidized Bed Granulation
- Effect of Several Cellulosic Binders on Particle Size Distribution of Granules Prepared by a High-Speed Mixer
- Release of Isosorbide Dinitrate from Polymer Film Dosage Forms and Absorption of This Drug through the Oral Mucosa of Rats
- Dissolution of Solid Dosage Form. VI. Dissolution of Nondisintegrating Single Component Tablets under Non-Sink Condition
- Hydrolysis of Acetylsalicylsalicylic Acid and Salicylsalicylic Acid in Aqueous Solution
- Preparation of Dry Powder Inhalation with Lactose Carrier Particles Surface-Coated Using a Wurster Fluidized Bed
- Effects of Surface Processing of Lactose Carrier Particles on Dry Powder Inhalation Properties of Salbutamol Sulfate
- Influence of Storage Humidity on the in Vitro Inhalation Properties of Salbutamol Sulfate Dry Powder with Surface Covered Lactose Carrier
- Effect of Surface Layering Time of Lactose Carrier Particles on Dry Powder Inhalation Properties of Salbutamol Sulfate
- Effect of Surface Covering of Lactose Carrier Particles on Dry Powder Inhalation Properties of Salbutamol Sulfate
- Preparation of Dry Powder Inhalation by Surface Treatment of Lactose Carrier Particles
- Evaluation of Flow Properties of Dry Powder Inhalation of Salbutamol Sulfate with Lactose Carrier
- Influence of Fatty Acid-Alcohol Esters on Percutaneous Absorption of Hydrocortisone Butyrate Propionate
- Interactions between Water and Pharmaceutical Polymers Determined by Water-Vapor Sorption Measurement and Differential Scanning Calorimetry
- Release of Lidocaine from Polymer Film Dosage Forms
- Measurement of Adhesive Force between Particles of Organic Substances and Polymer Substrates by the Centrifugal Separation Method : Effect of Electrostatic Charge
- Solid-State Interaction of Ibuprofen with Polyvinylpyrrolidone
- Influence of the Molecular Weight of Binding Agents on the Physical Properties of Granules and Tablets
- Dissolution of Solid Dosage Form. IV. Equation for the Non-sink Dissolution of a Monodisperse System
- Measurement of the Adhesive Force between Particles and a Substrate by Means of the Impact Separation Method. Effect of the Surface Roughness and Type of Material of the Substrate
- Effect of Temperature on the Sticking of Low Melting Point Materials
- Pharmaceutical Preparations of Crude Drug Powder. III.The Effects of the Physical Properties of the Binder Solution on the Characteristics of the Granule from the Mixed Powders
- Adsorption of Amino-acetamide Derivatives from 1-Octanol Solution by Silica Gel
- Influence of Formulation Change on Drug Release Kinetics from Hydroxypropylmethylcellulose Matrix Tablets
- Studies on Application of Wax Matrix System for Controlled Drug Release
- Influence of Drug Solubility and Matrix Structure on Release Rate of Drugs from Wax Matrix Tablets
- Flocculation Kinetics of the Monodisperse System. Computer Simulation of Flocculation by the Two-Dimensional Geometrical Random Coalescence Model
- Dissolution of Solid Dosage Form. V. New Form Equations for the Non-sink Dissolution of a Monodisperse System
- Dissolution and Simulation Curved for Log-Normal Particle-Size-Distributed Model Systems
- Changes of Surface Area in the Dissolution Process of Crystalline Substances. V. : Dissolution and Simulation Curves for Log-Normal Particle-Size-Distributed Model Systems
- Changes of Surface Area in the Dissolution Process of Crystalline Substances. IV. Dissolution and Simulation Curves Estimated from Changes of Surface Area and Cube Root Law
- Changes of Surface Area in the Dissolution Process of Crystalline Substances. III. : Dissolution and Simulation Curves for Symmetrical Particle-Size-Distributed Model Systems
- Changes of Surface Area in the Dissolution Process of Crystalline Substances. II. : Dissolution and Simulation Curves for Mixed Systems of Sieved Particles
- Preparation of Functional Composite Particles of Salbutamol Sulfate Using a 4-Fluid Nozzle Spray-Drying Technique
- Particle Design of Three-Component System for Sustained Release Using a 4-Fluid Nozzle Spray-Drying Technique
- Particle Design Using a 4-Fluid-Nozzle Spray-Drying Technique for Sustained Release of Acetaminophen
- Acetaminophen Particle Design Using Chitosan and a Spray-Drying Technique
- Improved Dissolution of an Insoluble Drug Using a 4-Fluid Nozzle Spray-Drying Technique
- Effect of Water Content on Sticking during Compression
- A Comparative Evaluation of the Mechanical Properties of Various Celluloses
- Preparation and Evaluation of a Compressed Tablet Rapidly Disintegrating in the Oral Cavity
- 生薬粉末の原料物性と製品物性との相関性
- Influence of Granulating Fluid Properties on Physical Properties of Kneading Mass and Granules
- Absorption of Ibuprofen Coated by Anhydrous Silicic Acid
- Flocculation Studies of Granulated Stearyl Alcohol on the Surface of Aqueous Media. III. : Changes of Agglomerate Structure in a Two-Dimensional System with Anionic Surface-Acitive Agent
- Flocculation Kinetics of the Didisperse System-Computer Simulation of Flocculation by the Random Coalescence Model
- Measurement of Adhesive Force between Particles and Polymer Films
- Effect of Particle Shape on the Compaction and Flow Properties of Powders
- Measurement of the Adhesive Force between Particles of Powdered Materials and a Glass Substrate by Means of the Impact Separation Method. III. : Effect of Particle Shape and Surface Asperity
- Measurements of the Adhesive Force between Particles of Powdered Organic Substances and a Glass Substrate by Means of the Impact Separation Method. II. Effect of Addition of Light Anhydrous Silicic Acid on the Adhesive Force of Potato Starch
- Dissolution of Solid Dosage Form. III. Equations for the Dissolution of a Nondisintegrating Single Component Tablet under a Nonsink Condition
- Dissolution of Solid Dosage Form. II. Equations for the Dissolution of Nondisintegrating Tablet under the Sink Condition
- Influence of Granulating Fluids in Hydroxypropycellulose Binder Solution on Physical Properties of Lactose Granules
- 糖類を用いた口腔内速崩壊性錠剤の調製
- Flocculation Studies of Granulated Stearyl Alcohol on the Surface of Aqueous Media. II. : Flocculation-Deflocculation Mechanism in a Two-Dimensional System
- Changes of Surface Area in the Dissolution Process of Crystalline Substances
- Measurements of the Adhesive Force between Particles of Powdered Organic Substances and a Glass Substrate by Means of the Impact Separation Method. I. Effect of Temperature
- Sustained Release Mechanisms of Wax Matrix System for Controlled Release
- Computer Simulation of Agglomeration by a Two-dimensional Random Addition Model. III. -Agglomeration Kinetics and Micromeritic Properties of Closely-packed Agglomerates of Heterogeneous Binary Circles-
- Simulation of Agglomeration. II. Two-dimensional Random Addition Model. (1)
- Caking of δ-D-Gluconolactone Powder
- 微粉体の充てん構造
- 粉体の充てん性に及ぼす水分の影響について
- Studies on Compaction of Powders. III. Compression Behavior of Several Powders under Low Pressure
- 遠心力場における粉体粒子の充てん特性