Dissolution of Solid Dosage Form. III. Equations for the Dissolution of a Nondisintegrating Single Component Tablet under a Nonsink Condition

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As equation was derived for the dissolution from the whole surface of a nondisintegrating single component tablet under a nonsink condition where the initial weight of a tablet is equal to the weight needed to saturate the solution. also, equations for several dissolution manners of the tablet under the nonsink condition were derived in the postulation of a dominant dissolution rate constant which determines the dissolution manner. The aplicability of these equations was examined by dissolution measurements with nondisintegrating single component tablets. Dissolution measurements of tablets prepared using the amount required to saturate the solution were conducted by masking their flat or side surface with adhesive tape in accordance with the conditions for the derivation of equations. These dissolution behaviors were treated by the use of derived equations to confirm the validity.Among the derived equations, dissolution from the whole surface of a tablet was expressed in the same form as the negative two-thirds law equation for particles, and a nondisintegrating single component tablet compressed by the use of stuitable amount was thought to behave like a single crystal. Also, equations, i.e., the negative two-thirds law and the negative square root law, thus derived were thought to be applicable for the dissolution of a nonspherical particle and crystal concerning the crystal's habit and its dissolution property.
公益社団法人日本薬学会の論文
1991-12-25

Dissolution of Solid Dosage Form. III. Equations for the Dissolution of a Nondisintegrating Single Component Tablet under a Nonsink Condition

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