Changes of Surface Area in the Dissolution Process of Crystalline Substances. II. : Dissolution and Simulation Curves for Mixed Systems of Sieved Particles

概要

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The dissolution of n-propyl p-hydroxybenzoate was followed under the sink condition. Experiments were conducted to evaluate the changes of surface area during the dissolution process of sieved crystalline particles. Whole particles were collected at a given time during the dissolution measurements, and the surface areas of the collected particles were estimated by using a LUZEX image analyzer. Hence, changes of surface area and surface area produced during the dissolution were estimated by graphical integration. Then the relationship between the surface producing rate constant and the initial particle size was estimated.Dissolution proceses of mixed samples were simulate on the basis of the changes of surface area and the surface producing rate constant obtained for the component samples. Dissolution measurements of ternary systems mixed to have various values of initial surface area were conducted to estimate the effect of components on the simulation of the dissolution processes, and the validity of the treatment was examined.
公益社団法人日本薬学会の論文
1989-02-25