Dissolution of Solid Dosage Form. VI. Dissolution of Nondisintegrating Single Component Tablets under Non-Sink Condition
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概要
- 論文の詳細を見る
Nondisintegrating single component tablets were dissolved under a non-sink condition, and the applicability of equations derived for the dissolution of particles with optional initial amounts, i.e., the z-law equation, Ln-z equation and Lg-z equation, was examined by comparing the dissolution rate constants and conformity of simulated value to measured value. The z-law equation expressed by a function of the initial amount used for dissolution measurement and solubility was reasonably applicable to the dissolutions of tablets with various initial amounts within solubility.The Ln-z equation well explained the dissolution process with initial amounts within around half of the solubility.The Lg-z equation, an extended application form of the z-law equation, was applicable to the dissolution with an initial amount close to the solubility. These application aspects for dissolutions of nondisintegrating single component tablets were almost the same as those observed for dissolution of particles reported previously, and it was confirmed that the z-law equation, the Ln-z equation and the Lg-z equation appropriately treated dissolutions carried out with optional initial amounts within solubility irrespective of whether particles or tablets. Once the dissolution rate constant was determined in advance, the dissolution process with optional initial amounts within solubility could be approximately predicted. It may become difficult to predict the dissolution process with increase in tablet weight, however.
- 公益社団法人日本薬学会の論文
- 1995-11-15
著者
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佐々木 緑
Faculty Of Pharmacy Meijo University
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米澤 頼信
名城大学薬学部
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砂田 久一
Faculty Of Pharmacy Meijo University
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和田 明子
Faculty Of Pharmacy Meijo University
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米澤 頼信
Faculty of Pharmacy, Meijo University
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川瀬 秀一
Faculty of Pharmacy, Meijo University
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Sasaki M
Faculty Of Pharmaceutical Sciences University Of Tokushima
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Wada Akiko
Faculty Of Pharmacy Meijo University
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米沢 頼信
Faculty Of Pharmacy Meijo University
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川瀬 秀一
Meijo Univ. Nagoya Jpn
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佐々木 緑
Faculty of Pharmaceutical Sciences, University of Tokushima
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