Preparation and Biological Activities of a Bivalent Poly(Ethylene Glycol) Hybrid Containing an Active Site and Its Synergistic Site of Fibronectin
スポンサーリンク
概要
- 論文の詳細を見る
A bivalent poly(ethylene glycol) or PEG hybrid of fibronectin-related peptides was prepared. An active site peptide (RGD) and its synergistic site peptide (PHSRN) of fibronectin were conjugated with an amino acid-type PEG (aaPEG) to form PHSRN-aaPEG-RGD. A moderate spatial array between RGD and PHSRN in fibronectin may be required for synergic activity. The bivalent hybrid exhibited potent cell spreading activity and exhibited potent anti-metastatic activity in a model of experimental metastasis with B16-BL6 cells in mice. PEG may serve as a spacer for maintaining the desired spatial array.
- 社団法人日本薬学会の論文
- 2002-09-01
著者
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Nakagawa Shinsaku
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ
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Kiwada Hiroshi
徳島大学 ヘルスバイオサイエンス研究部薬物動態制御学
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Kiwada Hiroshi
Faculty Of Pharmaceutifal Sciences The University Of Tokushima
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YAMAMOTO Yoko
Department of Materials Science and Engineering,Graduate School of Engineering,Osaka University
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真弓 忠範
Graduate School Of Pharmaceutical Sciences Kobe-gakuin Univ.
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真弓 忠範
大阪大学 薬 薬剤
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MAYUMI Tadanori
Department of Cell Therapeutics, Graduate School of Pharmaceutical Sciences, Kobe Gakuin University
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村上 智彦
神戸学院大学 薬
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Nakagawa S
Graduate School Of Pharmaceutical Sciences Osaka University
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Nakagawa S
Osaka Univ. Osaka Jpn
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Nakagawa Shinsaku
中華人民共和国
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Higashisaka Kazuma
Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Kamada Haruhiko
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Kamada Haruhiko
Laboratory Of Pharmaceutical Proteomics (lpp) National Institute Of Biomedical Innovation (nibio)
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Yoshioka Yasuo
Department Of Radiation Oncology Osaka University Graduate School Of Medicine
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Yoshioka Yasuo
大阪大学 医学系研究科放射線治療学
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前田 光子
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kiwada Hiroshi
Department Of Pharmacokinetics And Biopharmaceutics Faculty Of Pharmaceutical Sciences The Universit
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Yoshioka Yasuo
Dept. Of Radiation Oncology Osaka University Graduate School Of Medicine
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Tsujino Masaki
大阪大学 薬学研究科薬剤学
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川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kamiya Hiroyuki
Lab. For Molecular Design Of Pharmaceutics Fac. Of Pharmaceutical Sciences Hokkaido Univ.
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Keiko Hojo
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Hojo Keiko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Maeda Mitsuko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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SUSUKI Yuichi
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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OKAZAKI Ikuko
Graduate School of Environmental Earth Science, Hokkaido University
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KAMATA Haruhiko
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
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SASAKI Masahiko
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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NOMIZU Motoyoshi
Graduate School of Environmental Earth Science, Hokkaido University
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KAWASAKI Koichi
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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Kamada H
Yamagata Technopolis Foundation Yamagata Jpn
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Kamada Hitoshi
Institute For Life Support Technology Yamagata Promotional Organization For Industrial Technology
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Yoshioka Yasuo
Dept. Of Energy Science And Engineering Musashi Inst. Of Tech.
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Kawasaki Koichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Mayumi Tadanori
Faculty Of Pharmacy Osaka University
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Mayumi Tadanori
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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Mayumi Tadanori
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Science Osaka University
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Nakagawa Shinsaku
Dep. Of Biotechnology And Therapeutics Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Nakagawa Shinsaku
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Osaka University
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Sasaki M
Faculty Of Pharmaceutical Sciences University Of Tokushima
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Kamada H
Institute For Life Support Technology Yamagata Promotional Organization For Industrial Technology
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Okazaki Ikuko
Graduate School Of Environmental Earth Science Hokkaido University
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Susuki Yuichi
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
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Kiwada H
Faculty Of Pharmaceutifal Sciences The University Of Tokushima
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Yamashiro Y
Osaka Univ. Suita Jpn
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Nomizu M
School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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野水 基義
Tokyo University Of Pharmacy And Life Sciences
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Mayumi Tadanori
Faculty Of Pharmaceutical Sciences Kobe-gakuin University:faculty Of Pharmaceutical Sciences Osaka U
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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Momose T
大阪大学薬学部
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Hojo Keiko
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
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Nomizu Motoyoshi
Graduate School Of Environmental Earth Science Hokkaido University
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Kiwada Hiroshi
Department Of Pharmacokinetics And Biopharmaceutics Subdivision Of Biopharmaceutical Science Institu
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Yamamoto Yoko
Department Of Anesthesiology And Intensive Care Hamamatsu University School Of Medicine
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Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
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Nakagawa Shinsaku
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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