Calpain 10 as a Predictive Gene for Type 2 Diabetes : Evidence from a Novel Screening System Using White Blood Cells of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats (Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
The mRNA expression of type 2 diabetes-related genes in white blood cells (WBC) was examined before and after onset in Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The level of the calpain 10 (CAPN10) transcript was significantly decreased compared to control animals in WBC before and after onset. Significant decreases in this gene expression were also found in the major insulin-target tissues as well as WBC before onset. These results suggest that gene expression in WBC could be a useful screening system for predicting the incidence of type 2 diabetes before onset in OLETF rats, and that CAPN10 represents a potential candidate gene for predicting type 2 diabetes in human.
- 公益社団法人日本薬学会の論文
- 2003-12-01
著者
-
Kiwada Hiroshi
徳島大学 ヘルスバイオサイエンス研究部薬物動態制御学
-
Kiwada Hiroshi
Department Of Pharmacokinetics And Biopharmaceutics Faculty Of Pharmaceutical Sciences The Universit
-
Sato Y
Faculty Of Pharmaceutical Sciences The University Of Tokushima
-
HARASHIMA Hideyoshi
Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido Unive
-
Sato Yuichiro
Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido Unive
-
Kamiya Hiroyuki
Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido Unive
-
Kuwajima Masamichi
School Of Medicine The University Of Tokushima
-
Kuwajima Masamichi
Department Of Clinical Biology And Medicine School Of Medicine The University Of Tokushima
-
Harashima Hideyoshi
Laboratory For Molecular Design Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokkaido Univers
-
Harashima Hideyoshi
Department Of Pharmacokinetics And Pharmaceutics Graduate School Of Pharmaceutical Sciences The Univ
-
Kamiya Hiroyuki
産業医科大学産業生態科学研究所
-
Murata-kamiya Naoko
Inst. Indust. Ecolog. Sci. Univ. Occup. Environ. Hith.
-
Kuwajima Masamichi
Department Of 2nd Internal Medicine Faculty Of Medicine Oaka University
-
Kaji Hiroshi
Inst. Indust. Ecolog. Sci. Univ. Occup. Environ. Hith.
-
Harashima H
Laboratory for Molecular Design of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Hokkaido University
-
KAMIYA Hiroyuki
Laboratory for Molecular Design of Pharmaceutics and COE Program in the 21st Century, Graduate School of Pharmaceutical Sciences, Hokkaido University
関連論文
- Transgene expression efficiency from plasmid DNA delivered as a complex with histone H3
- Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5
- Isolation and culture of microvascular endothelial cells from murine inguinal and epididymal adipose tissues
- UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides
- Effects of Overexpression and Antisense RNA Expression of Orf17, a MutT-Type Enzyme
- Increased A:T→C:G Mutations in the mutT Strain upon 8-Hydroxy-dGTP Treatment : Direct Evidence for MutT Involvement in the Prevention of Mutations by Oxidized dGTP
- Optimized PEGylated Adenovirus Vector Reduces the Anti-vector Humoral Immune Response against Adenovirus and Induces a Therapeutic Effect against Metastatic Lung Cancer
- Comparison between a Multifunctional Envelope-Type Nano Device and Lipoplex for Delivery to the Liver
- イムノリポソームの膜流動性の差が及ぼす殺細胞効果と細胞内取り込み量への影響
- PK/PDを基盤とするDDS
- トランスフェリン修飾リポソームを用いたP-gpによる抗癌剤排出回避の試み
- 人工ベクターによる導入遺伝子の核内移行及び発現メカニズム(2)
- 人工ベクターによる導入遺伝子の核内移行及び発現メカニズム(1)
- Ligand-based targeted delivery of a peptide modified nanocarrier to endothelial cells in adipose tissue
- Creation of Novel Cell-Penetrating Peptides for Intracellular Drug Delivery Using Systematic Phage Display Technology Originated from Tat Transduction Domain(Biochemistry)
- Lactoferrin Inhibits Platelet Production from Human Megakaryocytes in Vitro(Molecular and Cell Biology)
- Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF : Useful Information for Designing Artificial Proteo-Antagonists
- Creation of Novel Protein Transduction Domain (PTD) Mutants by a Phage Display-Based High-Throughput Screening System(Biochemistry)
- Quality Enhancement of the Non-immune Phage scFv Library to Isolate Effective Antibodies(Highlighted paper selected by Editor-in-chief,Biochemistry)
- Histopathologic Study of the Pancreas Shows a Characteristic Lymphocytic Infiltration in Japanese Patients with IDDM
- Proliferation and differentiation of pancreatic β-cells: ultrastructural analysis of the pancreas in diabetic mice induced by selective alloxan perfusion
- Immunohistochemical Localization of Betacellulin a New Member of the EGF Family in Normal Human Pancreas and lslet Tumor Cells
- Development of new anti-TNF therapy
- Selective Enhancer of Tumor Vascular Permeability for Optimization of Cancer Chemotherapy (Pharmacognosy)
- MITO-Porter : a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion
- Establishment of Evaluation Method for siRNA Delivery Using Stable Cell Line Carrying the Luciferase Reporter Gene(Molecular and Cell Biology)
- In Vitro Efficacy of a Sterically Stabilized Immunoliposomes Targeted to Membrane Type 1 Matrix Metalloproteinase (MT1-MMP)(Biopharmacy)
- Preparation and Biological Activities of a Bivalent Poly(Ethylene Glycol) Hybrid Containing an Active Site and Its Synergistic Site of Fibronectin
- Complex Formation with Plasmid DNA Increases the Cytotoxicity of Cationic Liposomes(Biopharmacy)
- Gene Expression in Primary Cultured Mouse Hepatocytes with a Cationic Liposomal Vector, TFL-3 : Comparison with Rat Hepatocytes(Biopharmacy)
- Culture Time-Dependent Gene Expression in Isolated Primary Cultured Rat Hepatocytes by Transfection with the Cationic Liposomal Vector TFL-3
- Effect of Cationic Liposomes in an in Vitro Transcription and Translation System
- Noninvasive and persistent transfollicular drug delivery system using a combination of liposomes and iontophoresis
- Recognition of Nucleotide Analogs Containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein
- Development of Small, Homogeneous pDNA Particles Condensed with Mono-cationic Detergents and Encapsulated in a Multifunctional Envelope-type Nano Device(Biopharmacy)
- Efficient Cytoplasmic Protein Delivery by Means of a Multifunctional Envelope-type Nano Device(Biopharmacy)
- New NTP analogs: the synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX
- Amino Acids and Peptides.XXXVIII.Facile Synthesis of Laminin-Related Peptide-Poly(Ethylene Glycol)Hybrids by the Solid Phase Method
- Arsenic Trioxide Inhibits Human T Cell-Lymphotropic Virus-1-Induced Syncytiums by Down-Regulating gp46
- DNA Microarray Analysis of Whole Blood Cells and Insulin-Sensitive Tissues Reveals the Usefulness of Blood RNA Profiling as a Source of Markers for Predicting Type 2 Diabetes
- DNA Microarray Analysis of Type 2 Diabetes-Related Genes Co-regulated between White Blood Cells and Livers of Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
- Development of Efficient Packaging Method of Oligodeoxynucleotides by a Condensed Nano Particle in Lipid Envelope Structure(Biopharmacy)
- Characterization of Bovine Serum Factor Triggering the Lysis of Liposomes via Complement Activation
- Effect of Serum Components from Different Species on Destabilizing Hydrogenated Phosphatidylcholine-Based Liposomes
- Flavone Markedly Affects Phenotypic Expression of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus Strains Isolated Clinically(Miscellaneous)
- Calpain 10 as a Predictive Gene for Type 2 Diabetes : Evidence from a Novel Screening System Using White Blood Cells of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats (Biopharmacy)
- Identification of the Up- and Down-Regulated Genes in the Heart of Juvenile Visceral Steatosis Mice (Biochemistry/Molecular Biology)
- Functional Disorders of the Oxidative Phosphorylation System in the Heart Mitochondria of Mice with Juvenile Visceral Steatosis
- Expression and distribution of OCTN2 in mouse epididymis and its association with obstructive azoospermia in juvenile visceral steatosis mice
- Increased Expression of Carnitine Palmitoyltransferase I Gene is Repressed by Administering L-Carnitine in the Hearts of Carnitine-Deficient Juvenile Visceral Steatosis Mice
- Increased Expression of Carnitine Plamitoyltransferase I Gene Is Repressed by Administering L-Carnitine in the Hearts of Carnitine-Deficient Juvenile Visceral Steatosis Mice
- Pathologic mechanisms of influenza encephalitis with an abnormal expression of inflammatory cytokines and accumulation of mini-plasmin
- Reduced Carnitine Level Causes Death from Hypoglycemia : Possible Involvement of Suppression of Hypothalamic Orexin Expression During Weaning Period
- In Vivo Mutagenicities of Damaged Nucleotides Produced by Nitric Oxide and Ionizing Radiation(Biochemistry/Molecular Biology)
- Mutagenic effects of 8-hydroxy-dGTP in live mammalian cells
- Induction of Substitution and Deletion Mutations by 2-Hydroxyadenine during Replication in a HeLa Extract
- Incorporation of 8-hydroxyguanosine (8-oxo-7,8-dihydroguanosine) 5'-triphosphate by bacterial and human RNA polymerases
- Regioselective Conjugation of Chitosan with a Laminin-related Peptide, Tyr-Ile-Gly-Ser-Arg, and Evaluation of Its Inhibitory Effect on Experimental Cancer Metastasis
- Genome Wide Expression Analysis of White Blood Cells and Liver of Pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats Using a cDNA Microarray
- Transient activation of transgene expression by hydrodynamics-based injection may cause rapid decrease in plasmid DNA expression
- Cytotoxic Effect of Drosophila Deoxynucleoside Kinase Gene on Replicating Plasmid in HeLa Cells
- Induction of Various Mutations during PCRs with Manganese and 8-Hydroxy-dGTP
- Induction of Transition and Transversion Mutations during Random Mutagenesis PCR by the Addition of 2-Hydroxy-dATP (Biochemistry/Molecular Biology)
- PK-PD modeling of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine and the enhanced antitumor effect of its phospholipid derivatives in long-circulating liposomes
- Correction of Frameshift Mutations with Single-Stranded and Double-Stranded DNA Fragments Prepared from Phagemid/Plasmid DNAs(Miscellaneous)
- RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells
- Mutagenicity of 5-Formylcytosine, an Oxidation Product of 5-Methylcytosine, in DNA in Mammalian Cells
- Species Difference in Correlation between in Vivo/in Vitro Liposome-Complement Interactions
- In Vivo Studies on the Role of Complement in the Clearance of Liposomes in Rats and Guinea Pigs
- Enhanced antigen presentation and CTL activity by transduction of mature rather than immature dendritic cells with octaarginine-modified liposomes
- Cell cycle dependent transcription, a determinant factor of heterogeneity in cationic lipid-mediated transgene expression.
- Non-linear pharmacodynamics in a non-viral gene delivery system: Positive non-linear relationship between dose and transfection efficiency
- Gene Expression Analysis during Platelet-Like Particle Production in Phorbol Myristate Acetate-Treated MEG-01 Cells(Molecular and Cell Biology)
- Effects of 8-hydroxy-GTP and 2-hydroxy-ATP on in vitro transcription.
- Preparation of Laminin γ1 Chain Related Peptide Poly (Ethylene Glycol) Hybrid
- Pharmacokinetic Modeling of Species-dependent Enhanced Bioavailability of Trifluorothymidine by Thymidine Phosphorylase Inhibitor
- Novel lipidated sorbitol-based molecular transporters for non-viral gene delivery
- Efficient Short Interference RNA Delivery to Tumor Cells Using a Combination of Octaarginine, GALA and Tumor-Specific, Cleavable Polyethylene Glycol System
- Increased Gene Expression by Cationic Liposomes (TFL-3) in Lung Metastases Following Intravenous Injection(Biopharmacy)
- Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid
- A new peptide motif present in the protective antigen of anthrax toxin exerts its efficiency on the cellular uptake of liposomes and applications for a dual-ligand system
- Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria.
- Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake
- Safe and Efficient Drug Delivery System with Liposomes for Intrathecal Application of an Antivasospastic Drug, Fasudil
- Co-administration of Tacrolimus Suppresses Pharmacokinetic Modulation of Multiple Subcutaneously Administered Human Interferon-alpha in Beagle Dogs
- Intranuclear DNA Release Is a Determinant of Transfection Activity for a Non-viral Vector: Biocleavable Polyrotaxane as a Supramolecularly Dissociative Condenser for Efficient Intranuclear DNA Release
- Cell penetrating peptide-mediated systemic siRNA delivery to the liver
- Combination therapy of metronomic S-1 dosing with oxaliplatin-containing polyethylene glycol-coated liposome improves antitumor activity in a murine colorectal tumor model
- Unexpectedly Weak Impacts of Decreased p53 and Retinoblastoma Protein Levels on Mutagenesis by 8-Oxo-7, 8-dihydroguanine (8-Hydroxyguanine)
- Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery
- Effects of insulator cHS4 on transgene expression from plasmid DNA in a positive feedback system(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response
- Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy.
- CREB-binding protein transcription activation domain for enhanced transgene expression by a positive feedback system
- Intracellular stability of 2'-OMe-4'-thioribonucleoside modified siRNA leads to long-term RNAi effect
- Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy
- Intravenous Administration of Polyethylene Glycol-Coated (PEGylated) Proteins and PEGylated Adenovirus Elicits an Anti-PEG Immunoglobulin M Response
- Ex-Vivo/in-Vitro Anti-polyethylene Glycol (PEG) Immunoglobulin M Production from Murine Splenic B Cells Stimulated by PEGylated Liposome
- Intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide(BIOMEDICAL ENGINEERING)
- The Polyethyleneglycol Dilemma: Advantage and Disadvantage of PEGylation of Liposomes for Systemic Genes and Nucleic Acids Delivery to Tumors