In Vivo Mutagenicities of Damaged Nucleotides Produced by Nitric Oxide and Ionizing Radiation(Biochemistry/Molecular Biology)
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概要
- 論文の詳細を見る
To evaluate the in vivo mutagenicities of damaged DNA precursors (deoxyribonucleoside 5'-triphosphates) produced by exposure to nitric oxide (NO) and ionizing radiation, five damaged deoxyribonucleotides (deoxyxan-thosine triphosphate, deoxyoxanosine triphosphate, dITP, dUTP, and 8-hydroxy-dATP) were introduced into competent Escherichia coli cells. Their mutagenic potentials were assayed using the chromosomal rpoB gene as a mutagenesis target. In contrast to 8-hydroxy-dGTP and 2-hydroxy-dATP, which were examined in an earlier study, none of these damaged deoxyribonucleotides significantly increased the rpoB mutant frequency. These results suggest that these five damaged deoxyribonucleotides are weakly mutagenic in vivo if at all. Thus their contributions to mutations induced by NO and ionizing radiation may be small.
- 公益社団法人日本薬学会の論文
- 2005-03-01
著者
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Hori Mika
北海道大学 薬学研究科
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Hori Mika
北海道大学 薬学研究院
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Hori Mika
Hokkaido University Graduate School Of Pharmaceutical Sciences
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HARASHIMA Hideyoshi
Hokkaido University Graduate School of Pharmaceutical Sciences
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ISHIGURO Chieko
Hokkaido University Graduate School of Pharmaceutical Sciences
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KAMIYA Hiroyuki
Hokkaido University Graduate School of Pharmaceutical Sciences
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Harashima Hideyoshi
Department Of Pharmacokinetics And Pharmaceutics Graduate School Of Pharmaceutical Sciences The Univ
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Kamiya Hiroyuki
産業医科大学産業生態科学研究所
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Murata-kamiya Naoko
Inst. Indust. Ecolog. Sci. Univ. Occup. Environ. Hith.
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Kaji Hiroshi
Inst. Indust. Ecolog. Sci. Univ. Occup. Environ. Hith.
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