Development of Efficient Packaging Method of Oligodeoxynucleotides by a Condensed Nano Particle in Lipid Envelope Structure(Biopharmacy)

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概要

• 論文の詳細を見る

• An efficient delivery system is required if antisense oligodeoxynucleotides (ODN) are to be utilized for gene therapy. We report herein on the development of a novel ODN delivery system, ODN-encapsulated nano particles (ODN-ENP) using an efficient and simple packaging method. The ODN-ENP consists of a condensed ODN particle and a lipid envelope, which can be equipped with various functional devices for the efficient delivery of ODN with a small diameter (150nm). The encapsulation efficiency and ODN recovery of ODN-ENP were significantly higher than those of other packaging methods, such as a stabilized antisense-lipid particles method or a freeze-thaw method. Furthermore, the time required for the preparation of the ODN-ENP was shorter than the other methods. The method developed in this study is a simple and efficient packaging method for ODN with a condensed nano particle in lipid-envelope structure.

• 公益社団法人日本薬学会の論文
• 2005-10-01

著者

• HARASHIMA Hideyoshi

  Graduate School of Pharmaceutical Sciences, Hokkaido University

• 佐々木 茂樹

  九州大学

• 佐々木 茂貴

  九州大学

• Yamada Yuma

  Lab. For Molecular Design Of Pharmaceutics Fac. Of Pharmaceutical Sciences Hokkaido Univ.

• Yamada Yuma

  Laboratory For Molecular Design Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokkaido Univers

• AKITA Hidetaka

  Graduate School of Pharmaceutical Sciences, Hokkaido University

• Kogure Kentaro

  Dep. Of Biophysical Chemistry Kyoto Pharmaceutical Univ.

• Suhara Tetsuya

  National Institute Of Radiological Sciences

• Akita Hidetaka

  Lab. For Molecular Design Of Pharmaceutics Fac. Of Pharmaceutical Sciences Hokkaido Univ.

• Sasaki Shigeki

  Faculty of Pharmaceutical Sciences, Kyushu University

• SASAKI Shigeki

  Graduate School of Pharmaceutical Sciences, Kyushu University

• 佐々木 茂貴

  九州大学大学院薬学研究院

• Sasaki Shigeki

  Graduate School Of Pharmaceutical Sciences Kyushu University

• 佐々木 茂貴

  九州大学薬学部

• Inoue Kaori

  National Institute Of Radiological Sciences

• YAMADA Yuma

  Graduate School of Pharmaceutical Sciences, Hokkaido University

• KOGURE Kentaro

  Graduate School of Pharmaceutical Sciences, Hokkaido University

• NAKAMURA Yoshio

  Graduate School of Pharmaceutical Sciences, Hokkaido University

• NAGATSUGI Fumi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Harashima Hideyoshi

  Department Of Pharmacokinetics And Pharmaceutics Graduate School Of Pharmaceutical Sciences The Univ

• Akita Hidetaka

  Graduate School Of Pharmaceutical Sciences Hokkaido University

• Nagatsugi Fumi

  Inst. Of Multidisciplinary Res. For Advanced Materials Tohoku Univ.

• 佐々木 茂貴

  九州大学薬学部製薬化学科

• Nagatsugi Fumi

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Inoue Kaori

  National Inst. Of Radiological Sciences Jpn

• 山田 勇磨

  北海道大学大学院薬学研究科薬剤分子設計学分野

• Sasaki Shigeki

  Graduate School Of Pharmaceutical Sciences Kyushu University:crest Japan Science And Technology Agen

• Kogure Kentaro

  Kyoto Pharmaceutical University

• Nakamura Yoshio

  Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University

• Harashima Hideyoshi

  Graduate School Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology Corporation (jst)

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