NOVEL BICYCLIC CHIRAL CROWN ETHERS HAVING A p-XYLENEDIOXY UNIT WITH INPROVED COMPLEX STABILITY AND RATE-ENHANCEMENT IN THE INTRA-COMPLEX THIOLYSIS OF α-AMINO ACID ESTER SALTS

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概要

• 論文の詳細を見る

• Novel bicyclic chiral crown ethers having an α, α'-p-xylenedioxy unit were synthesized. Crown dithiol 1 with a p-xylenedioxy bridge-structure perfomed intra-complex thiolysis with α-amino acid p-nitrophenyl ester HBr salts much faster than the corresponding dithiol 3 without the bridge-structure. A ^1H-NMR study suggested that the increased rate of intracomplex thiolysis is due to increased stability of the intermediary complex during the reaction.

• 公益社団法人日本薬学会の論文
• 1991-02-25

著者

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 佐々木 茂貴

  Faculty of Pharmaceutical Sciences, Kyusyu University

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

• SASAKI Shigeki

  Graduate School of Pharmaceutical Sciences, Kyushu University

• 佐々木 茂貴

  Faculty Of Pharmaceutical Sciences Kyushu University

• 安酸 達郎

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 佐々木 茂貴

  Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)faculty Of Pharmaceutical Sc

• 安酸 達郎

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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