Stereochemical Studies. L. Reductive Decyanization of α-Amino Nitriles with Sodium in Liquid Ammonia. An Alternate Method for the Application to the Asymmetric Synthesis of optically Active Natural Products

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概要

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• An alternate method for reductive decyanization of α-amino nitriles to the corresponding amines was exploited using sodium in liquid ammonia. This method eliminated the limitation encountered in the reaction with sodium borohydride. Using this new process, optically active α-amino nitrile (8) was decyanized to 9 without racemization.

• 公益社団法人日本薬学会の論文
• 1977-10-25

著者

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

• 富岡 清

  Faculty of Pharmaceutical Sciences, University of Tokyo

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