Biomimetic Studies Using Astificial Systems. V. : Design and Synthesis of Novel Water-Soluble Bis-cyclophanes

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概要

• 論文の詳細を見る

• Novel water-soluble bis-cyclophanes (3a-c) with quaternary ammonium nitrigens, composed of two untis of QCP44 (2) connected by appropriate bridges, were synthesized as hosts having two discrete hydrophobic cavities to bind two guest molecules simultaneously or a single guest molecule via double recognition in neutral water. Glutaryl, terephthaloyl and isophthaloyl groups were used as spacers to bridge the two cyclophane units. THe bridge formation was carried out using 5 as an intermediate, in which three of the four nitrogens of CP44 (1) were protected. The details of the synthesis and characterization of duplex hosts (3a-c) as well as of the reference compounds (9-11) are described.

• 公益社団法人日本薬学会の論文
• 1989-09-25

著者

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 古賀 憲司

  東京大学

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

• 小田嶋 和徳

  Faculty of Pharmaceutical Sciences, University of Tokyo

• LAI Chung-Fang

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 小田嶋 和徳

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Lai Chung-fang

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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