Stereoselective Reactions. III. A highly Efficient Method for the Asymmetric Synthesis of 2-Alkylcycloalkanones via Chiral Chelated Lithioenamines
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概要
- 論文の詳細を見る
A novel method was devised for the asymmetric synthesis of 2-alkylcycloalkanones (10) by metalation and alkylation of chiral cyclic imines (8), using an optically active α-amino acid tert-butyl ester (7) as a chiral source. The present method provides 2-alkylcycloalkanones (10) of unequivocally predictable absolute configuration in quite high enantiomeric purities, allowing easy recovery of the chiral reagent without any racemization for reuse. The present method is also shown to be applicable for the creation of an asymmetric quaternary carbon atom, as exemplified in the synthesis of 2-methyl-2-phenylcycloalkanones (13). The mechanism of the reaction is proposed.
- 公益社団法人日本薬学会の論文
- 1979-11-25
著者
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古賀 憲司
Faculty of Pharmaceutical Sciences, University of Tokyo
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橋本 俊一
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Koga Kenjiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
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橋本 俊一
Faculty Of Pharmaceutical Sciences Hokkaido University
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