Chemistry of Amino Acids. III. Reduction of Phenylalanine Ethyl Ester and Its Derivatives with Sodium Borohydride.

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概要

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• Eleven kinds of ethyl 2-substituted-3-phenylpropionates (Ia〜k) were reduced with sodium borohydride under a similar reaction condition and the effects of the α-substituents on the reduction were examined. Some esters (Ia〜c, e, f, j, k) were hydrolyzed with alkali. The obtained data of hydrolysis rate constants were roughly parallel to those of ester reductions. These results may be explained by considering both inductive and steric effects of the α-substituents.

• 公益社団法人日本薬学会の論文
• 1967-12-25

著者

• 山田 俊一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 関 英男

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

• 関 英男

  Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

関連論文

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