Stereochemical Studies. LII. Studies on the Stereochemical Courese in Deaminative Bromination of 3,5-Dichloro-L-tyrosine and in Amination of the Corresponding α-Bromo Acid. Existence of Strong Neighboring "Phenoxide"Group Participation

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概要

• 論文の詳細を見る

• It has become apparent that deaminative bromination of 3,5-dichloro-L-tyrosine (L-4) to the corresponding α-bromo acid ((-)-5) occurs with retention of configuration, and that amination of this bromo acid to the starting amino acid (L-4) occurs also with retention of configuration. The unusual stereochemical course in this amination step was found to be due to the strong neighboring aryl group participation as a phenoxide form.

• 公益社団法人日本薬学会の論文
• 1978-01-25

著者

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

• 荘 祚敏

  Institute of Applied Chemistry, National Chiao-Tung University

• 荘 祚敏

  Institute Of Applied Chemistry National Chiao-tung University

• 荘 祚敏

  Faculty of Pharmaceutical Sciences, University of Tokyo

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