Stereochemical Studies. XI. Changes in the Stereochemical Course of 1,2-Asymmetric Induction in the Reduction of N-Substituted 2-Aminopropiophenone Derivatives with Sodium Borohydride

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概要

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• Changes in the stereochemical course of 1,2-asymmetric induction in the reduction of N-substituted 2-aminopropiophenones with sodium borohydride were examined. It was concluded that substitution for the two hydrogens of the amino group by two bulky groups is important for the synthesis of threo-isomer, while at least one of the two hydrogens of the amino group must be left attached for the synthesis of erythro-isomer. This stereochemical outcome was considered to be attributable to the steric phenomena.

• 公益社団法人日本薬学会の論文
• 1972-03-25

著者

• 古賀 憲司

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 山田 俊一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Koga Kenjiro

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University

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