Stereoselective Reactions. V. Design of the Asymmetric Synthesis of Lignan Lactones. Synthesis of optically Active Podorhizon and Deoxypodorhizon by 1,3-Asymmetric Induction
スポンサーリンク
概要
- 論文の詳細を見る
A novel method for the asymmetric synthesis of both enantiomers of 2,3-disubstituted-butanolides (8) was devised using a readily available (S)-4-hydroxymethyl-4-butanolide 4-derivative (6) as a chiral source in the asymmetric induction and as the carbon framework of 8. Application of this method to the asymmetric total synthesis of podorhizon (23) and deoxypodorhizon (4) is described.
- 公益社団法人日本薬学会の論文
- 1982-12-25
著者
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古賀 憲司
Faculty of Pharmaceutical Sciences, University of Tokyo
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辻原 健二
Research Laboratories, Tanabe Seiyaku Co., Ltd.
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古賀 憲司
東京大学
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辻原 健二
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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辻原 健二
Faculty of Pharmaceutical Sciences, University of Tokyo
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水口 英道
Faculty of Pharmaceutical Sciences, University of Tokyo
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水口 英道
Faculty Of Pharmaceutical Sciences University Of Tokyo
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