Stereoselective Reactions.XXXIV.^<1) Enantioselective Deprotonation of Prochiral 4-Substituted Cyclohexanones Using Chiral Bidentate Lithium Amides Having a Bulky Group Instead of a Phenyl Group on the Chiral Carbon
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概要
- 論文の詳細を見る
Using chiral bidentate lithium amides having a bulky group instead of a phenyl group on the chiral carbon, enantioselective deprotonation of prochiral 4-substituted cyclohexanones in the presence of excess trimethylsilyl chloride was examined in THF in the absence and in the presence of HMPA. It is shown that enantioselectivity of the reactions decreases as the substituent on the chiral carbon of the chiral Iithium amides and the substituent at the 4-position of cyclohexanones become reasonably bulky. An eight-membered cyclic transition state model is proposed for this deprotonation reaction.
- 公益社団法人日本薬学会の論文
- 2001-04-01
著者
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古賀 憲司
東京大学
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Koga Kenjiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
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MOTOHASHI Shigeyasu
College of Pharmacy, Nihon University
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TORIYAMA Masaharu
College of Pharmacy, Nihon University
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SUGASAWA Keizo
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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TOKUTAKE Norio
College of Pharmacy, Nihon University
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KOGA Kenji
Research and Education Center for Materials Science, Nara Institute of Science and Technology
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Motohashi Shigeyasu
College Of Pharmacy Nihon University
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古賀 憲司
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
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Sugasawa Keizo
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Tokutake N
College Of Pharmacy Nihon University
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Toriyama Masaharu
College Of Pharmacy Nihon University
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Koga Kenji
Research And Education Center For Materials Science Nara Institute Of Science And Technology
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