Stereoselective Reactions. VIII. Stereochemical Requirement for the Benzylic Oxidation of Lignan Lactone. A Highly Selective Synthesis of the Antitumor Lignan Lactone Steganacin by the Oxidation of Stegane
スポンサーリンク
概要
- 論文の詳細を見る
A highly efficient synthesis of the antitumor steganin lignan steganacin (1) was accomplished. Bromination of stegane (7) with N-bromosuccinimide followed by treatment with aqueous tetrahydrofuran afforded steganol (3) in 85% yield. Acetylation of 3 gave 1 in 72% yield. Stegane (7) was also oxidized with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in AcOH to give 1 directly in 10% yield. Stereochemical requirements for the benzylic oxidation of dibenzocyclooctadiene lignan lactones are discussed.
- 公益社団法人日本薬学会の論文
- 1985-02-25
著者
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古賀 憲司
Faculty of Pharmaceutical Sciences, University of Tokyo
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Koga Kenjiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
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富岡 清
Faculty of Pharmaceutical Sciences, University of Tokyo
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富岡 清
京都大学大学院薬学研究科
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水口 英道
Faculty of Pharmaceutical Sciences, University of Tokyo
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水口 英道
Faculty Of Pharmaceutical Sciences University Of Tokyo
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石黒 恒男
Faculty of Pharmaceutical Sciences, University of Tokyo
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石黒 恒男
Central Research Laboratories Ajinomoto Co. Inc.
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