ENANTIOSELECTIVE HORNER-WADSWORTH-EMMONS REACTION USING CHIRAL LITHIUM 2-AMINOALKOXIDES
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概要
- 論文の詳細を見る
Chiral lithium 2-aminoalkoxides ((1R, 2S)-4) were applied as chiral bases for the enantioselective Horner-Wadsworth-Emmons reaction between achiral phosphonates (2) and 4-tert-butylcyclohexanone (1). A chiral olefin ((R)-3b) was obtained in up to 52% enantiomeric excess (ee). It is shown that the formation of the lithium aldolate intermediate is reversible and is not responsible for the asymmetric induction.
- 公益社団法人日本薬学会の論文
- 1997-04-15
著者
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古賀 憲司
東京大学
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Koga Kenji
Faculty Of Science And Engineering Tokyo University Of Science
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Koga Kenji
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Koga Kenjiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
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KUMAMOTO Takuya
Faculty of Pharmaceutical Sciences, University of Tokyo
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古賀 憲司
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
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Kumamoto T
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Kumamoto Takuya
Faculty of Pharmaceutical Sciences, Musashino University
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