Stereoselective Reactions. XXVII. Solution Structures of a Chiral Tridentate Lithium Amide in Relation to Enantioselective Deprotonation of 4-tert-Butylcyclohexanone
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概要
- 論文の詳細を見る
^6Li- and ^<15>N-NMR spectroscopic studies on the solution structures of a chiral tridentate lithium amide have revealed that it exists as a chelated monomer in which the lithium is tri-coordinated, as a chelated dimer in which the lithium is tetra-coordinated, or as a mixture of these two species depending upon the solvent used. It is concluded that lower Lewis acidity of the tri- and tetra-coordinated lithium compared to the di-coordinated lithium makes tridentate lithium amides inferior to dibentate lithium amides as bases in enantioselective deprotonation reaction.
- 公益社団法人日本薬学会の論文
- 1997-09-15
著者
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古賀 憲司
東京大学
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Koga Kenji
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Koga Kenjiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
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SATO Daisaku
Graduate School of Pharmaceutical Sciences, University of Tokyo
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KAWASAKI Hisashi
Graduate School of Pharmaceutical Sciences, University of Tokyo
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Kawasaki H
Graduate School Of Pharmaceutical Sciences University Of Tokyo
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古賀 憲司
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
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Sato D
Graduate School Of Pharmaceutical Sciences University Of Tokyo
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