ENANTIOSELECTIVE α-ALKYLATION OF PHENYLACETIC ACID USING A CHIRAL BIDENTATE LITHIUM AMIDE AS A CHIRAL AUXILIARY

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概要

• 論文の詳細を見る

• Enantioselective alkylation at the α-position of phenylacetic acid (1) can be realized in up to 68% ee by treating the dilithiated 1 with alkyl halides in the presence of a chiral bidentate lithium amide ((R)-3).

• 公益社団法人日本薬学会の論文
• 1997-12-15

著者

• Koga Kenji

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Matsuo Jun-ichi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

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• Rate Enhancement with High Ratio of the Monoalkylated Product to the Dialkylated Product in the Alkylation of the Lithium Enolate of 1-Tetralone with Reactive Alkyl Halides
• ENANTIOSELECTIVE α-ALKYLATION OF PHENYLACETIC ACID USING A CHIRAL BIDENTATE LITHIUM AMIDE AS A CHIRAL AUXILIARY

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