Rate Enhancement with High Ratio of the Monoalkylated Product to the Dialkylated Product in the Alkylation of the Lithium Enolate of 1-Tetralone with Reactive Alkyl Halides

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概要

• 論文の詳細を見る

• The reactions of the lithium enolate of 1-tetralone with reactive alkyl halides were examined in the absence and in the presence of 3 eq of various ligands for the lithium. It is shown that the rates of the reactions are enhanced greatly in the presence a tetradentate amine (1,1,4,7,10,10-hexamethyltriethylenetetramine), and the ratio of the monoalkylated product to the dialkylated product is increased under shorter reaction times.

• 公益社団法人日本薬学会の論文
• 2000-10-01

著者

• Koga Kenji

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Koga Kenji

  Graduate School Of Pharmaceutical Sciences University Of Tokyo:(present Addresses)research And Educa

• Goto Mariko

  Graduate School Of Pharmaceutical Sciences University Of Tokyo:(present Addresses)research Laborator

• Shindo Mitsuru

  Graduate School Of Pharmaceutical Sciences University Of Tokyo:(present Addresses)faculty Of Pharmac

• AKIMOTO Koh-ichi

  Graduate School of Pharmaceutical Sciences, University of Tokyo

• AOKI Kazumasa

  Graduate School of Pharmaceutical Sciences, University of Tokyo

• Aoki Kazumasa

  Graduate School Of Pharmaceutical Sciences University Of Tokyo:(present Addresses)new Lead Research

• Akimoto Koh-ichi

  Graduate School Of Pharmaceutical Sciences University Of Tokyo:(present Addresses)fine Chemicals Dep

• Gotoh Mariko

  Graduate School of Pharmaceutical Sciences, University of Tokyo

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• Rate Enhancement with High Ratio of the Monoalkylated Product to the Dialkylated Product in the Alkylation of the Lithium Enolate of 1-Tetralone with Reactive Alkyl Halides
• ENANTIOSELECTIVE α-ALKYLATION OF PHENYLACETIC ACID USING A CHIRAL BIDENTATE LITHIUM AMIDE AS A CHIRAL AUXILIARY

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