Effects of Fatty Acid Sucrose Esters on Ceftibuten Transport by Rat Intestinal Brush-Border Membrane Vesicles
スポンサーリンク
概要
- 論文の詳細を見る
The effects of fatty acid sucrose esters on membrane lipid dynamics and ceftibuten transport by rat intestinal brush-border membrane vesicles (BBMV) were examined to clarify the differences in the action of mono- and poly-acyl sucrose esters on the drug transport. Fatty acid sucrose mono-acyl ester (SS) inhibited ceftibuten transport by BBMV similar to the action of polyoxyethylene sorbitans (Tweens), while fatty acid sucrose polyacyl ester mixtures (F-160 and F-140) did not affect the drug transport by BBMV. SS but not F-160 and F-140 caused an increase in the anisotropy of 1,6-diphenyl-1,3,5-hexatriene (DPH)- and 1-(4-trimethylammonium-phenyl)-6-phenyl-1,3,5-hexatriene iodide (TMA-DPH)-labeled BBMV in a concentration-dependent manner. Thus, the uptake of ceftibuten by BBMV was strongly correlated with the lipid fluidity of BBMV, in the outer layer and in the inner hydrophobic regions; however, there was no strong correlation between the membrane lipid fluidity and the drug uptake by BBMV. The micelle size and the size distribution of F-160 and F-140 were larger and more widely dispersed, respectively, compared to those of SS and Tweens. These results suggest that the effects of fatty acid sucrose esters on ceftibuten transport by BBMV are related to the dispersion parameter of these pharmaceutical adjuvants.
- 公益社団法人日本薬学会の論文
- 1998-07-15
著者
-
村上 正裕
京都薬科大学 薬剤
-
MURAKAMI Masahiro
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto Un
-
村上 正裕
天藤製薬
-
Koga Kenjiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
-
Koga Kenjiro
Division Of Pharmaceutical Information Research Laboratory For Development Of Medicine Faculty Of Ph
-
Murakami Masahiro
Kyoto Research Laboratory Amato Pharmaceutical Products
-
KAWASHIMA Susumu
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokuriku University
-
Murakami Masahiro
Department Of Biopharmaceutics Kyoto Pharmaceutical University
-
古賀 憲司
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hokuriku University
-
Murakami M
Showa Univ. Tokyo Jpn
-
Kawashima S
Faculty Of Pharmaceutical Science Hokuriku University
-
村上 正裕
京都薬大 薬剤学
-
村上 正裕
京都薬科大学
-
Murakami Masahiro
Department Of Aquatic Bioscience Graduate School Of Agricultural And Life Sciences The University Of
-
MURAKAMI Masahiro
Department of Anatomy, Kurume University School of Medicine
関連論文
- Stereochemical Studies. XIII. Determination of the Absolute Configuration of Mercaptosuccinic Acid by Chemical Correlation with Glyceraldehyde
- Studies on Opically Active Amino Acids. VII. Stereoselective Synthesis of l-Norephedrine Hydrochloride from D-Phenylalanine
- Studies on Optically Active Amino Acids. V. Synthesis of Optically Active α-Aminoalcohols by the Reduction of α-Amino Acid Esters with Sodium Borohydride
- Studies on Optically Active Amino Acids. IV. A New Synthetic Approach to Chloramphenicol Base from L-Phenylalanine.
- NMRを用いて糖タンパク質分子中の糖鎖を原子レベルで見る
- キトサンカプセルを用いた潰瘍性大腸炎治療薬の大腸特異的送達法の開発
- Construction of Carbon Frameworks through β-Carbon Elimination Mediated by Transition Metals
- P-27 Asymmetric Synthesis of (-)-α-Herbertenol Using Enantioselective C-C Bond Cleavage as the Key Step
- Synthesis of 1H-Inden-1-ol Derivatives via Rhodium-catalyzed Annulation of o-Acylphenylboronic Acids with Alkynes
- Addition/Ring-Opening Reaction of Organoboronic Acids to Cyclobutanones Catalyzed by Rhodium(I)/P(t-Bu)_3 Complex
- 腸管出血性大腸菌O157に対する乳酸縮合物(AD300)の感染防御効果
- Papyriflavonol A from Broussonetia papyrifera Inhibits the Passive Cutaneous Anaphylaxis Reaction and Has a Secretory Phospholipase A_2-Inhibitory Activity
- 新規 TRH 類縁体 Azetirelin の消化管吸収改善(2)吸収促進剤を用いた Azetirelin 経口吸収促進製剤の設計
- 新規 TRH 類縁体 Azetirelin の消化管吸収改善(1)Azetirelin 経口投与時の Bioavailability に及ぼす各種要因の検討
- リゾチームの消化管吸収性およびリンパ移行性に及ぼす脂肪酸修飾の影響に関する研究
- 消化管吸収促進剤の起炎性の in vitro 評価 - ヒスタミン受容体を介した粘膜透過性の亢進の寄与 -
- In situ single-pass perfusion 法を用いた各種吸収促進剤の有効性と安全性に関する検討
- 吸収助剤の安全性 : 薬物腸管吸収の増大における各種炎症性メディエーターの寄与
- 吸収促進剤の腸管粘膜透過性亢進作用における inflammatory mediator の関与
- アフリカツメガエル摘出肺組織を用いた薬物の肺上皮細胞透過性評価
- 脂肪酸修飾および超音波照射によるペプチドの皮膚透過性の改善
- Synergistic Anti-tumor Effects of Mitomycin C and Bile Salts against L1210 Cells
- Intestinal Absorption of Azetirelin, a New Thyrotropin-Releasing Hormone (TRH) Analogue. II. In Situ and in Vitro Absorption Characteristics of Azetirelin from the Rat Intestine
- Intestinal Absorption of Azetirelin, a New Thyrotropin-Releasing Hormone (TRH) Analogue. I. Possible Factors for the Low Oral Bioavailability in Rats
- 消化管粘膜における透過性亢進シグナルの伝達機構
- P-06 環状ポリ乳酸 (CPL) の抗腫瘍作用(第 4 報) : 担癌マウスにおける腫瘍増殖抑制効果と副作用について
- STUDIES ON THE PROMOTING EFFECT OF LIPID-SURFACTANT MIXED MICELLES (MM) ON INTESTINAL ABSORPTION OF COLLOIDAL PARTICLES. DEPENDENCE ON PARTICLE SIZE AND ADMINISTRATION SITE
- ROLE OF THE DISPERSION SYSTEMS CONTAINING FUSOGENIC LIPIDS ON ENHANCED ABSORPTION OF POORLY ABSORBABLE DRUGS FROM THE GASTROINTESTINAL TRACT
- INTESTINAL ABSORPTION OF CARBOXYFLUORESCEIN ENTRAPPED IN LIPOSOMES IN COMPARISON WITH ITS ADMINISTRATION WITH LIPID-SURFACTANT MIXED MICELLES
- Stereoselective Reactions. XVI. : Total Synthesis of (-)-β-Bourbonene by Employing Asymmetric (2+2) Photocycloaddition Reaction of Chiral Butenolide
- 21 不斉(2+2)光環化付加反応による抗腫瘍性ジテルペン、スパトールの不斉全合成へのアプローチ
- Reproducibility of luteinizing hormone hypersecretion in different phases of the menstrual cycle in polycystic ovary syndrome
- Stereoselective Reactions. II. Asymmetric Synthesis of β-Substituted Aldehydes by Michael Reaction using Chiral α, β-Unsaturated Aldimines
- Stereoselective Reactions. I. A highly Efficient Asymmetric Synthesis of β-Substituted Aldehydes via 1,4-Addition of Grignard Reagents to optically Active α, β-Unsaturated Aldimines
- Stereochemical Studies. LIV. A Biogenetic-type Asymmetric Synthesis of optically Active Galanthamine from L-Tyrosine
- MOLECULAR RECOGNITION AND DISCRIMINATION OF HYDROPHOBIC GUESTS IN WATER BY QUATERNARY AMMONIUM CYCLOPHANES HAVING DIARHLMETHANE UNITS
- DESIGN, SYNTHESIS, AND PROPERTIES OF NOVEL WATER-SOLUBLE CYCLOPHANES HAVING NAPHTHYLPHENYLMETHANE UNITS AS HOSTS FOR ALIPHATIC AND AROMATIC GUESTS
- ASYMMETRIC REDUCTION OF ARYLGLYOXYLIC ACIDS VIA・HOST-GUEST COMPLEX FORMATION WITH OPTICALLY ACTIVE PARACYCLOPHANES
- Activation of a Cyclobutanone Carbon-Carbon Bond over an Aldehyde Carbon-Hydrogen Bond in the Rhodium-catalyzed Decarbonylation
- Palladium-Catalyzed Coupling Reactions of N-Methoxy-N-methylcarbamoyl Chloride for the Synthesis of N-Methoxy-N-methylamides
- Regio-and Stereoselective Incorporation of a ^C Nuclide into D-ribo-Phytosphingosine via SmI_2-Mediated C-C Formation with ^C-Labeled Isocyanide
- Preparation of (Alkaneimidoyl)lanthanides and Their Reactions with Carbonyl Compounds
- Alkyllithium-Mediated Anomalous Trimerization of 2,6-Xylyl Isocyanide
- Stereoselective Reactions. III. A highly Efficient Method for the Asymmetric Synthesis of 2-Alkylcycloalkanones via Chiral Chelated Lithioenamines
- Stereoselective Reactions. XXII. Design and Synthesis of Chiral Chelated Lithium Amides for Enantioselective Reactions
- REINVESTIGATION ON THE OPTICAL PURITIES OF OPTICALLY ACTIVE TRIMETHYLSILYL ENOL ETHERS OF 4-SUBSTITUTED CYCLOHEXANONES
- Biomimetic Studies Using Artificial Systems. VI. Design and Synthesis of Novel Cyclophanes Having Eight Carboxyl Groups on the Aromatic Rings
- A NOVEL WATER-SOLUBLE CYCLOPHANE AS A HOST FOR CATIONIC, ANIONIC, AND NEUTRAL AROMATIC GUESTS
- モレキュラ-・クレフトとキラル識別--Rebek教授の研究から (モレキュラ-・キラリティ---高次機能分子の開拓と創薬への展開をめざして) -- (キラル識別のメカニズムを追う)
- Chromatographic Separation of Armatic Guest Compounds by a Gel-Immobilized Water-Soluble Cyclophane
- LAPAROSCOPIC TREATMENT FOR PERFORATED APPENDICITIS WITH PELVIC ABSCESS
- Stereoselective Reactions. XIX. Asymmetric Dihydroxylation of Olefins by Employing Osmium Tetroxide-Chiral Amine Complexes
- 68 不斉酸化反応を用いるアントラサイクリン系抗生物質の短段階不斉合成(口頭発表の部)
- 4酸化オスミウムを用いたオレフィンの不斉酸化反応 (1987年の化学-6-)
- ENANTIOSELECTIVE DARZENS REACTION : ASYMMETRIC SYNTHESIS OF trans-GLYCIDIC ESTERS MEDIATED BY CHIRAL LITHIUM AMIDES
- Amino Acids and Peptides. II. A One-Step Synthesis of Atropine and Other Related Alkaloids from dl-Phenylalanine 3α-Tropanyl Ester
- 8 PhenylalanineからTropic acidへの非酵素的転換反応
- Stereochemical Studies. XVII. Nitrous Acid Deaminations of (R)-α-Methylphenylalanine and Its Methyl Ester in Acetic Acid
- Taste effects of oligopeptides in a Vietnamese fish sauce
- Stereoselective Reactions. XX. Synthetic Studies on Optically Active β-Lactams. III. Stereocontrolled Synthesis of Chiral Intermediate to (+)-Thienamycin from D-Glucose
- Clove Oil Prevents Glycyrrhizin Gel Formation in Aqueous Solution
- Preparation and Rectal Absorption of Highly Concentrated Glycyrrhizin Solution(Biopharmacy)
- A Simple Method for the Selection of a Suitable Emulsifier Based on Color Difference
- Effects of Fatty Acid Glycerol Esters on Intestinal Absorptive and Secretory Transport of Ceftibuten
- Modification of Ceftibuten Transport by Changes in Lipid Fluidity Caused by Fatty Acid Glycerol Esters
- Effects of Fatty Acid Sucrose Esters on Ceftibuten Transport by Rat Intestinal Brush-Border Membrane Vesicles
- Contribution of Hydrophobicity of Nonionic Detergents to Membrane Lipid Fluidity and Disopyramide Uptake by Rat Intestinal Brush-Border Membrane Vesicles
- Stereoselective Reactions. XVIII. : Synthesis and Cytotoxicity of the Demethyl Derivatives of Steganes
- ナフタレン環への共役付加反応--不斉反応への展開 (1990年の化学-8-)
- ASYMMETRIC α-ALKYLATION OF CYCLOHEXANONE BY MEDIATION OF A CHIRAL LIGAND AND THE LEAVING-GROUP EFFECT OF ELECTROPHILES ON ENANTIOSELECTIVITY
- 新しい制がん剤の合成 (1989年の化学-8-)
- Effectiveness and Toxicity Screening of Various Absorption Enhancers Using Caco-2 Cell Monolayers
- 虚血性大腸炎モデルラットにおける薬物吸収 : 辺縁血管結紮時間の組織障害性およびアンチピリンの吸収に及ぼす影響
- ラット小腸刷子縁膜内へのβ-ラクタム剤の二次性能動輸送に及ぼす緩衝剤濃度およびその組成の影響
- 小腸刷子縁膜内取り込みにおける up-hill 現象に対する緩衝能および緩衝液組成の関与
- セフチブテン腸管輸送に及ぼす界面活性剤の影響とその疎水性および分散性との関連
- Stereoselective Reactions.XXXIV.^
- Stereoselective Reactions.XXXIII^. Design and Synthesis of Chiral Bidentate Amines Having a Bulky Group on the Chiral Carbon
- キラル塩基を用いる不斉合成
- Stereoselective Reactions. XXVII. Solution Structures of a Chiral Tridentate Lithium Amide in Relation to Enantioselective Deprotonation of 4-tert-Butylcyclohexanone
- ENANTIOSELECTIVE HORNER-WADSWORTH-EMMONS REACTION USING CHIRAL LITHIUM 2-AMINOALKOXIDES
- Approaches to Catalytic Asymmetric Formation and Reactions of Lithium Enolates
- Isolated metastasis to the gallbladder from hepatocellular carcinoma
- Lysophosphatidylserine Enhances Exogenous Type II Phospholipase A_2-Induced Activation of Rat Serosal Mast Cells
- Exogenous Type-II Phospholipase A_2 Stimulates Prostaglandin Synthesis in Rat Liver-Derived BRL-3A Cells in the Presence of Tumor Necrosis Factor α
- Racemization and Deracemization of Poly(quinoxaline-2,3-diyl)s
- Development of an Oral Formulation of Azetirelin, a New Thyrotropin-Releasing Hormone (TRH) Analogue, Using n-Lauryl-β-D-maltopyranoside as an Absorption Enhancer
- IMPROVEMENT OF INTESTINAL ABSORPTION OF PEPTIDES AND PROTEINS BY CHEMICAL MODIFICATION WITH FATTY ACIDS
- CONTRIBUTION OF SH-PROTEINS TO PROMOTIVE TRANSMUCOSAL PERMEATION OF POORLY ABSORBABLE DYE WITH OLEATE IN RAT COLON
- Synthesis of Stereodefined 3-Alkylideneoxindoles by Palladium-catalyzed Reactions of 2-(Alkynyl)aryl Isocyanates with Thiols and Alcohols
- Synthesis of Oxindoles by Palladium-catalyzed C-H Bond Amidation
- Synthesis of gem-Difluoroalkenes via β-Fluoride Elimination of Organorhodium(I)
- Successful outcome after resection of liver metastasis arising from an extraadrenal retroperitoneal paraganglioma that appeared 9 years after surgical excision of the primary lesion
- Synthesis and Structural Analysis of Oligo(naphthalene-2, 3-diyl)s
- Nickel-Catalyzed [4+2+2]-Type Annulation Reaction of Cyclobutanones with Diynes and Enynes
- Stereoselective Synthesis of 3-(1-Cyanoalkylidene)oxindoles by Palladium-catalyzed Cyclization Reaction of 2-(Alkynyl)aryl Isocyanates with Copper(I) Cyanide
- Eight-membered Ring Formation via Olefin Insertion into a Carbon-Carbon Single Bond
- Palladium-Catalyzed Allylation Reaction of Alkynylborates
- Synthesis of β-Amino Acid Derivatives by Nickel(0)-mediated Sequential Addition of Carbon Dioxide and Dibenzoyldiazene onto Unsaturated Hydrocarbons
- A Simple Method for the Selection of a Suitable Emulsifier Based on Color Difference