Lysophosphatidylserine Enhances Exogenous Type II Phospholipase A_2-Induced Activation of Rat Serosal Mast Cells
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概要
- 論文の詳細を見る
We have previously shown that exogenous type II phospholipase A_2 (PLA_2) alone elicits degranulation of mast cells, including rat serosal mast cells (SMC) and mouse bone marrow-derived mast cells (BMMC). Here we report that lysophosphatidylserine (lysoPS), a co-factor for activation of rodent SMC in response to some tyrosine kinase-coupled agonists, enhanced type II PLA_2-elicited histamine release from rat SMC. In contrast, mouse BMMC was insensitive to lysoPS. Our findings demonstrate a novel route for activation of SMC in that type II PLA_2 can act as a direct activator of SMC with enhancement by lysoPS, which is generated from membrane phosphatidylserine possibly by the action of the same enzyme.
- 公益社団法人日本薬学会の論文
- 1996-03-15
著者
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INOUE Keizo
Faculty of Pharmaceutical Sciences, Teikyo University
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村上 正裕
京都薬科大学 薬剤
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村上 正裕
天藤製薬
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MURAKAMI Makoto
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University
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KUDO Ichiro
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University
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村上 正裕
京都薬大
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Kudo I
Showa Univ. Tokyo
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Inoue Keizo
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Hara N
Department Of Health Chemistry Faculty Of Pharmaceutical Sciences University Of Tokyo:department Of
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Hara Noriko
Department Of Anesthesiology Faculty Of Medicine Kyushu University
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Inoue K
Department Of Pharmacology Kobe Pharmaceutical University
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Inoue K
Third Department Of Internal Medicine Kansai Medical University
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Kudo I
Department Of Health Chemistry School Of Pharmaceutical Sciences Showa University
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Kudo Ichiro
Department Of Health Chemicals School Of Pharmaceutical Science Showa University
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Murakami M
Showa Univ. Tokyo Jpn
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Inoue Keizo
Department Of Health Chemistry Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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村上 正裕
京都薬大 薬剤学
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村上 正裕
京都薬科大学
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Inoue Keizo
Department Of Biochemistry And Molecular Biology Indiana University
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Murakami Makoto
Department Of Agricultural Engineering Faculty Of Agriculture Hokkaido University
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