Hot Topics in Phospholipase A_2 Field(Diversity of Phospholipase A_2 Enzymes)
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概要
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As detailed in previous reviews, phospholipase A_2 (PLA_2) enzymes belonging to the secretory PLA_2 (sPLA_2), cytosolic PLA_2 (cPLA_2), and Ca^<2+>-independent PLA_2 (iPLA_2) families may play specific physiologic and pathologic roles. In the past two years, there have been considerable advances in the understanding of the regulatory functions of individual PLA_2s. This short article focuses on the latest topics in the PLA_2 field, which have offered new insights into this intriguing enzyme family. Specifically, I describe a novel cellular action and unexplored in vivo functions of sPLA_2, expanding regulatory aspects of cPLA_2, and unique functional roles of iPLA_2 in apoptosis, Ca^<2+> homeostasis, and myocardial ischemia.
- 公益社団法人日本薬学会の論文
- 2004-08-01
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- Hot Topics in Phospholipase A_2 Field(Diversity of Phospholipase A_2 Enzymes)
- Induction of PYPAF1 during In Vitro Maturation of Mouse Mast Cells