Papyriflavonol A from Broussonetia papyrifera Inhibits the Passive Cutaneous Anaphylaxis Reaction and Has a Secretory Phospholipase A_2-Inhibitory Activity

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概要

• 論文の詳細を見る

• Papyriflavonol A, a new prenylated flavonol isolated from Broussonetia papyrifera, selectively inhibits recombinant human secretory phospholipase A_2s (sPLA_2s). Papyriflavonol A was found to inhibit human group IIA and V sPLA_2s potently and irreversibly in a dose-dependent manner, with respective IC_50 values of 3. 9 and 4. 5 μM. The inhibitory effects of papyriflavonol A against bovine group IB (IC_50 of 76. 9μM) and the human group X (IC_50 of 225μM) sPLA_2s were weaker than those against human group IIA and V sPLA_2s, and human group IIF sPLA_2 was not inhibited. In addition, papyriflavonol A potently inhibited the stimulus-induced production of leukotriene C_4 with an IC_50 value of approximately 0. 64μM in mouse bone marrow-derived mast cells. In addition, papyriflavonol A significantly reduced IgE-dependent passive cutaneous anaphylaxis in rats. These results indicate that papyriflavonol A provides a basis for novel types of antiinflammatory drugs.

• 社団法人日本薬学会の論文
• 2003-03-01

著者

• LEE Eunkyung

  College of Pharmacy, Yeungnam University

• LIN Chang

  College of Pharmacy, Yeungnam University

• CHANG Hyeun

  College of Pharmacy, Yeungnam University

• Lin Chang

  College Of Pharmacy Yeungnam University

• Lin Chang

  韓国

• 村上 正裕

  京都薬科大学 薬剤

• Kim Hyun

  College Of Pharmacy Kangwon National University

• SON Kun

  Department of Food Nutrition, Andong National University

• MOON Tae

  College of Pharmacy, Yeungnam University

• 村上 正裕

  天藤製薬

• Son K

  Department Food & Nutriton Andong National University

• Chang Hyeun

  College Of Pharmacy Yeungnam University

• MURAKAMI Makoto

  Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University

• KUDO Ichiro

  Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University

• Kang Sam

  韓国

• Moon Tae

  韓国

• Moon T

  Pulmonary Research Group Department Of Medicine University Of Alberta

• KWAK Wie

  SK Chemicals

• RHYN Hyeun

  College of Pharmacy, Yeungnam University

• JUNG Hyejin

  College of Pharmacy, Yeungnam University

• KWON Dong

  College of Pharmacy, Yeungnam University

• KAXG Sam

  Natural Products Research Institute, Seoul National University

• Kwak Wie

  韓国

• Rhyn Hyeun

  College Of Pharmacy Yeungnam University

• Ju H

  College Of Pharmacy Yeungnam University

• Kudo I

  Showa Univ. Tokyo

• Moon Tae

  College Of Pharmacy Yeungnam University

• Kwon Dong

  College Of Pharmacy Yeungnam University

• Moon Tae

  Pulmonary Research Group Department Of Medicine University Of Alberta

• Chang Hyeun

  Coll. Of Pharmacy Yeungnam Univ.

• Murakami Masahiro

  Kyoto Research Laboratory Amato Pharmaceutical Products

• Son Kun

  Department Food & Nutriton Andong National University

• Kang S

  Natural Products Research Institute And College Of Pharmacy Seoul National University

• Lee E

  Yeungnam Univ. Gyongsan Kor

• Kudo I

  Department Of Health Chemistry School Of Pharmaceutical Sciences Showa University

• Kudo Ichiro

  Department Of Health Chemicals School Of Pharmaceutical Science Showa University

• Murakami M

  Showa Univ. Tokyo Jpn

• Chang H

  College Of Pharmacy Yeungnam University

• Kim Hyun

  College Of Pharmacy And Research Institute Of Drug Development Chonnam National University

• 村上 正裕

  京都薬大 薬剤学

• 村上 正裕

  京都薬科大学

• Murakami Makoto

  Department Of Agricultural Engineering Faculty Of Agriculture Hokkaido University

• Lee Eunkyung

  College Of Pharmacy Yeungnam University

• Kim Hyun

  College Of Electrical & Computer Engineering Chungbuk National University

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