Expression of Cyclooxygenase-2 and Pro-inflammatory Cytokines Induced by 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) in Human Mast Cells Requires NF-κB Activation

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概要

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• Mast cells are critical for initiating innate immune and inflammatory responses by releasing a number of pro-inflammatory mediators. The potential immunomodulatory properties of hydrogenated aromatic hydrocarbons have been the subject of extensive investigation, as the immune system is a sensitive target for hydrogenated aromatic hydrocarbon toxicity. In this report, the effects of polychlorinated biphenyl (PCB) on the expression of cyclooxygenase-2 and pro-inflammatory cytokines such as interleukin-1β (IL-1β), IL-6 and tumor necrosis factor (TNF)-α in the human leukemic mast cell line were investigated. TNF-α and IL-1β expressed their respective mRNA in the presence or absence of PCB, while cyclooxygenase-2 (COX-2) and IL-6 mRNA expression were highly induced by PCB after 2 h. Moreover, pre-treatment with the nuclear factor (NF)-κB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed COX-2, TNF-α and IL-1β induction and reduced the IL-6 mRNA levels induced by PCB. The NF-κB activity was determined by electrophoretic mobility shift analysis (EMSA) using an oligonucleotide containing a consensus NF-κB binding sequence. Stimulating the cells with PCB activated NF-κB. However, pre-treating them with a NF-κB pathway inhibitor, pyrrolidine dithiocarbamate, suppressed PCB-induced NF-κB activation. This suggests that PCB induces cycloxoygenase-2 and pro-inflammatory cytokine expression, and that this induction occurs through NF-κB.

• 社団法人日本薬学会の論文
• 2002-09-01

著者

• LEE Eunkyung

  College of Pharmacy, Yeungnam University

• LIN Chang

  College of Pharmacy, Yeungnam University

• CHANG Hyeun

  College of Pharmacy, Yeungnam University

• Lin Chang

  College Of Pharmacy Yeungnam University

• Lin Chang

  韓国

• MOON Tae

  College of Pharmacy, Yeungnam University

• Chang Hyeun

  College Of Pharmacy Yeungnam University

• Moon Tae

  韓国

• Moon T

  Pulmonary Research Group Department Of Medicine University Of Alberta

• JUNG Hyejin

  College of Pharmacy, Yeungnam University

• KWON Okyun

  College of Pharmacy Yeungnam University

• NAM Kyung-Soo

  Department of Pharmacology, College of Medicine, Dongguk University

• BAEK Suck

  Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University

• MIN Hae-Ki

  Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University

• Baek S

  Department Of Biochemistry And Molecular Biology College Of Medicine Yeungnam University

• Ju H

  College Of Pharmacy Yeungnam University

• Min Hae-ki

  Department Of Internal Medicine Medical College Of Virginia Virginia Commonwealth University

• Moon Tae

  College Of Pharmacy Yeungnam University

• Nam Kyung-soo

  Department Of Pharmacology College Of Medicine Dongguk University

• Nam Kyung-soo

  Department Of Pharmacology College Of Medicine And Intractable Disease Research Center Dongguk Unive

• Moon Tae

  Pulmonary Research Group Department Of Medicine University Of Alberta

• Chang Hyeun

  Coll. Of Pharmacy Yeungnam Univ.

• Lee E

  Yeungnam Univ. Gyongsan Kor

• Chang H

  College Of Pharmacy Yeungnam University

• Baek Suck

  Department Of Biochemistry And Molecular Biology College Of Medicine Yeungnam University

• Lee Eunkyung

  College Of Pharmacy Yeungnam University

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