Alleviation of OVA-Induced Airway Inflammation by Flowers of Inula japonica in a Murine Model of Asthma
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概要
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The flowers of Inula japonica (Inulae Flos) have long been used in traditional medicine for treating inflammatory diseases. The effects on OVA-induced asthmatic mice of an Inulae Flos extract (IFE) were evaluated in this study. The anti-asthmatic effects of IFE were determined by observing eosinophil recruitment, airway hyper-responsiveness (AHR), Th2 cytokine and IgE levels, and lung histopathology. The IFE treatment effectively reduced the percentage of eosinophils and Th2 cytokines in the bronchoalveolar lavage fluid (BALF) when compared to the levels in OVA-induced mice. IFE also suppressed AHR induced by aerosolized methacholine in OVA-induced mice. The results of the histopathological studies indicate that inflammatory cell infiltration and mucus hypersecretion were both inhibited by the IFE administration when compared to the effect on OVA-induced mice. The IFE treatment also suppressed the serum IgE levels and decreased Th2 cytokines in the supernatant of cultured splenocytes. These results suggest that IFE may have therapeutic potential against asthma.
- 2011-05-23
著者
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JIN Meihua
College of Pharmacy, Yeungnam University
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Kim Jin
韓国
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Son Jong
College Of Pharmacy Yeungnam University
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Chang Hyeun
College Of Pharmacy Yeungnam University
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Chang Hyeun
Coll. Of Pharmacy Yeungnam Univ.
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Yang Ju
College Of Pharmacy Yeungnam University
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Lee E
Yeungnam Univ. Gyongsan Kor
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Chang H
College Of Pharmacy Yeungnam University
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Kim Jong
College Of Oriental Medicine Daegu Haany University
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PARK Young
Research and Development Division, Daegu Gyeongbuk Institute for Oriental Medicine Industry
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LEE Youn
College of Medicine, Yeungnam University
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CHOI Jeon
Research and Development Division, Daegu Gyeongbuk Institute for Oriental Medicine Industry
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LI Ying
College of Pharmacy, Yeungnam University
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LEE Jiean
Research and Development Division, Daegu Gyeongbuk Institute for Oriental Medicine Industry
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LI Xian
College of Pharmacy, Yeungnam University
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KIM Keuk-Jun
Department of Clinical Pathology, Tae Kyeung College
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Li Ying
College Of Pharmacy Yeungnam University
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Lee Eunkyung
Research And Development Division Daegu Gyeongbuk Institute For Oriental Medicine Industry
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Jin Mei
College Of Pharmacy Yeungnam University
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Lee Youn
College Of Medicine Yeungnam University
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Li Xian
College Of Pharmacy Yeungnam University
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Park Young
Research And Development Division Daegu Gyeongbuk Institute For Oriental Medicine Industry
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Kim Jong
College Of Medicine Yeungnam University
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Lee Eunkyung
College Of Pharmacy Yeungnam University
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Kim Keuk-jun
Department Of Clinical Pathology Tae Kyeung College
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Choi Jeon
Research And Development Division Daegu Gyeongbuk Institute For Oriental Medicine Industry
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Lee Jiean
Research And Development Division Daegu Gyeongbuk Institute For Oriental Medicine Industry
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