Protective Effect of Puerariae Radix on Oxidative Stress Induced by Hydrogen Peroxide and Streptozotocin(Molecular and Cell Biology)

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概要

• 論文の詳細を見る

• This study evaluated the protective effect of Puerariae radix against the oxidative stress induced by hydrogen peroxide (H_2O_2) and streptozotocin in vitro and in vivo, respectively. The ethanol extract scavenged intracellular reactive oxygen species (ROS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and prevented lipid peroxidation. This radical scavenging activity of the ethanol extract protected the cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed to H_2O_2. Furthermore, this extract reduced the formation of apoptotic cells induced by H_2O_2, which was demonstrated by the decreased number of sub G_1 hypo-diploid cells and apoptotic cell body formation. The extract increased the activities of the cellular antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Administration of the extract to the streptozotocin induced diabetic rats decreased the blood glucose levels. The diabetic rats showed low activities of superoxide dismutase and catalase in the liver, and the ethanol extract increased the CAT activity. The increased level of lipid peroxidation in the diabetic rats reverted to near normal levels after being treated with the extract. This study showed that Puerariae radix was effective in the amelioration of diabetes, which may be a consequence of its antioxidant potential.

• 社団法人日本薬学会の論文
• 2005-07-01

著者

• LEE Jae

  Department of Metallurgy, The University of Tokyo

• KIM Jin

  Departments of Surgery, Seoul National University College of Medicine

• Kim Jin

  韓国

• Son Jong

  Coll. Of Pharmacy Yeungnam Univ.

• Lee Jae-hwa

  Department Of Materials Science And Engineering Graduate School Of Engineering Osaka University

• Lee Jae-hwa

  韓国

• Lee Jae

  Department Of Bioscience And Biotechnology Silla University

• KOH Young

  Department of Orthopaedic Surgery, Ewha Women's University

• Kang Kyoung

  School Of Medicine And Applied Radiological Science Research Institute Cheju National University

• YOU Ho

  Dppartment of Pharmacology, College of Medicine, Chosun University

• KANG Kyoung

  Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,

• HYUN Jin

  Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,

• CHAE Sungwook

  Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,

• YOU Ho

  Department of Pharmacology, College of Medicine, Chosun University

• Hyun Jin

  School Of Medicine And Applied Radiological Science Research Institute Cheju National University

• You Ho

  Dppartment Of Pharmacology College Of Medicine Chosun University

• You Ho

  Department Of Pharmacology College Of Medicine Chosun University

• Kim Jin

  Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar

• Chae Sungwook

  Department Of Biochemistry College Of Medicine And Applied Radiological Science Research Institute C

• Lee Jae

  Department Of Acupuncture & Moxibustion College Of Oriental Medicine

• Chae S

  Department Of Biochemistry College Of Medicine And Applied Radiological Science Research Institute C

• Koh Young

  Department Of Orthopaedic Surgery Ewha Women's University

• Hyun Jin

  Department Of Biochemistry College Of Medicine Cheju National University

• KOH Young

  Department of Psychiatry, College of Medicine, Cheju National University

• KANG Kyoung

  College of Medicine, Jeju National University

• KOH Young

  Department of Biochemistry, Osaka University Medical School

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