Gastrodia elata Blume and an Active Component, p-Hydroxybenzyl Alcohol Reduce Focal Ischemic Brain Injury through Antioxidant Related Gene Expressions(Pharmacognosy)

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概要

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• Ischaemic stroke is a leading cause of death and long-lasting disability. Gastrodia elata blume (GEB) is a Chinese herb that is widely used to treat convulsive disorders, such as epilepsy, and p-hydroxybenzyl alcohol (HBA) is the active ingredient in GEB. The present study was conducted to evaluate the effects of GEB and HBA on the brain damage and transcriptional levels of Protein disulfide isomerase (PDI) and 1-Cys peroxiredoxin (1-Cys Prx) genes known to play a role in antioxidant systems after transient focal ischemia in the rat brain. Focal ischemia was induced in rats by middle cerebral artery occlusion (MCAO). All animals underwent ischemia for 1 h, followed by 24 h of reperfusion. Coronal brain slices were stained with 2,3,5-triphenyltetrazolium chloride or total RNA was extracted for the analysis of gene expression. Histopathologic analysis revealed a significant (p<0.05) decrease in infarct size in the ipsilateral brain with GEB extracts or HBA. Moreover, the levels of PDI and 1-Cys Prx transcription were significantly increased in the GEB extract- or HBA-treated group compared with the untreated group (p<0.05). This study therefore indicated that GEB and HBA provide neuroprotection by preventing brain damage through the increased expression of genes encoding antioxidant proteins after transient focal cerebral ischemia and may be effective as neuroprotective agents at the cellular and molecular levels in the brain.

• 社団法人日本薬学会の論文
• 2005-06-01

著者

• LEE Jae

  Department of Metallurgy, The University of Tokyo

• Lee Chae

  Institute Of Industrial Medicine Inje University

• Hong Jeong

  Department Of Food Science And Engineering Inje University

• YU Seong

  School of Biotechnology and Biomedical Science, Institute of Basic Science, Inje University

• KIM Ju

  School of Biotechnology and Biomedical Science, Institute of Basic Science, Inje University

• HAN Jeong

  Department of Food Science and Engineering, Inje University

• KIM Hye

  Faculty of Pharmaceutical Sciences, Okayama University

• KANG Sung

  School of Biotechnology and Biomedical Science, Institute of Basic Science, Inje University

• Kim Hye

  Faculty Of Pharmaceutical Science Okayama University

• Han Jeong

  Department Of Food Science And Engineering Inje University

• Yu Seong

  School Of Biotechnology And Biomedical Science Institute Of Basic Science Inje University

• Lee Jae

  Department Of Food Science And Engineering Inje University

• Kim Hye

  Faculty Of Pharmaceutical Sciences Okayama University

• Lee Jae

  Department Of Acupuncture & Moxibustion College Of Oriental Medicine

• Han Jeong

  Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo

• Hong Jeong

  Department Of Family Medicine College Of Medicine Pusan National University

• Kang Sung

  School Of Biotechnology And Biomedical Science Inje University

• Hong Jeong

  Department Of Applied Mathematics Korea Maritime University

• Kang Sung

  School Of Biotechnology And Biomedical Science Institute Of Basic Science Inje University

• Kim Ju

  School Of Biotechnology And Biomedical Science Institute Of Basic Science Inje University

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