Effects of Mechanical Stimuli and Microfiber-Based Substrate on Neurite Outgrowth and Guidance(CELL AND TISSUE ENGINEERING)
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概要
- 論文の詳細を見る
We introduced mechanical stimuli and micropatterned substrate with microfibers to investigate their effects on neurite outgrowth along with nerve growth factor in vitro. Two types of surface morphology were used: a surface that was coated by laminin alone and a surface where in microfibers was added on the laminin surface. PC-12 cells were seeded on both surface types and cultured for 2 d. The magnitudes of shear stresses ranged from 0.10 to 1.50 Pa. Two days after stimulation by shear stress, neurite outgrowth and its direction were measured by F-actin staining and digital image processing. When a shear stress of 0.50 Pa was applied, neurons were most highly aligned with microfibers. The average length of neurite outgrowth with microfibers was largest at a shear stress of 0.25 Pa. The results suggest that micropatterned fibers and fluid-induced shear stress are promising for stimulating neurite outgrowth in a desired direction.
- 社団法人日本生物工学会の論文
- 2006-02-25
著者
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KIM In
Department of Radiation Oncology, Seoul National University College of Medicine
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Kim Young
Department Of Electronics Engineering Korea Advance Intitute Of Science & Technology
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Shin Ji
National Research Laboratory Of Cellular And Biomechanical Engineering Department Of Biomedical Engi
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Shin Ji
National Res. Lab. Of Cellular And Biomechanical Engineering Dep. Of Biomedical Engineering Inje Uni
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LEE Yong
Department of Materials Science & Engineering, Sungkyunkwan University
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Shin Jung-woog
National Res. Lab. Of Cellular And Biomechanical Engineering Dep. Of Biomedical Engineering Inje Uni
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Kim In
Department Of Animal Resource And Sciences Dankook University
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Shin Jung-woog
National Research Laboratory Of Cellular And Biomechanical Engineering Department Of Biomedical Engi
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Kim Su-hyang
National Research Laboratory Of Cellular And Biomechanical Engineering Department Of Biomedical Engi
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Kim Su-hyang
National Res. Lab. Of Cellular And Biomechanical Engineering Dep. Of Biomedical Engineering Inje Uni
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Shin Ho
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Kim Young
Department Of Agricultural Chemistry The University Of Tokyo
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KANG Sung
School of Biotechnology and Biomedical Science, Institute of Basic Science, Inje University
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Park Su
Department of Future Technology, Korea Institute of Machinery & Materials
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Shin Jung-Woog
Department of Biomedical Engineering, Inje University
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Park Su
Department Of Biomedical Engineering Inje University
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Kim Su-Hyang
Department of Biomedical Engineering, Inje University
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Lee Yong
Department Of Agricultural Chemistry Division Of Applied Life Science Graduate School Gyeongsang Nat
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Shin Jung-woog
Department Of Biomedical Engineering Inje University
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Kim In
Department Of Biomedical Engineering Inje University
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Lee Yong
Department Of Biomedical Engineering Inje University
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Kang Sung
School Of Biotechnology And Biomedical Science Inje University
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Shin Ho
Department Of Biomedical Engineering Inje University
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Lee Yong
Depart. Of Oncology Yonsei Univ. Wonju College Of Medicine
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