Kaempferol Attenuates 2-Deoxy-D-ribose-Induced Oxidative Cell Damage in MC3T3-E1 Osteoblastic Cells(Biopharmacy)
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概要
- 論文の詳細を見る
Reducing sugar, 2-deoxy-D-ribose (dRib), produces reactive oxygen species through autoxidation and protein glycosylation and causes osteoblast dysfunction. Kaempferol, a natural flavonoid, was investigated to determine whether it could influence dRib-induced cellular dysfunction and oxidative cell damage in the MC3T3-E1 mouse osteoblastic cell line. Osteoblastic cells were treated with 30mM dRib in the presence or absence of kaempferol (10^<-9>-10^<-5>M) and markers of osteoblast function and lipid peroxidation were subsequently examined. Kaempferol (10^<-9>-10^<-5>M) significantly inhibited the dRib-induced decrease in growth of MC3T3-E1 osteoblastic cells. In addition, treatment with kaempferol resulted in a significant elevation of alkaline phosphatase (ALP) activity, collagen content, and mineralization in the cells. Treatment with kaempferol increased osteoprotegerin (OPG) secretion and decreased malondialdehyde (MDA) contents of MC3T3-E1 osteoblastic cells in the presence of 30mM dRib. Taken together, these results suggest that kaempferol inhibits dRib-induced osteoblastic cell damage and may be useful for the treatment of diabetes-related bone disease.
- 2009-04-01
著者
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Kim Sung
Department of Bioengineering and Technology, College of Engineering, Kangwon National University
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Kim Young
Department of Obstetrics and Gynecology, Women's Cancer Clinic, Yonsei University College of Medicin
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Kim Young
Department Of Electronics Engineering Korea Advance Intitute Of Science & Technology
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SUH Kwang
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine
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CHOI Eun-Mi
Plant Resources Research Institute. Duksung Women's University
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KWON Mikwang
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine
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CHON Suk
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine
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OH Seungjoon
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine
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WOO Jeong-Taek
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine
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KIM Jin-Woo
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine
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Chon Suk
Department Of Endocrinology And Metabolism Kyung Hee University School Of Medicine:research Institut
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Sur Kwang
Department Of Endocrinology And Metabolism Kyung Hee University School Of Medicine:research Institut
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Choi Eun-mi
Plant Resources Research Institute. Duksung Women's University
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Kim Jin
Department Of Endocrinology And Metabolism Kyung Hee University School Of Medicine:research Institut
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Kim Jin-woo
Department Of Electronic Materials Engineering Kwangwoon University
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Kwon Mikwang
Department Of Endocrinology And Metabolism Kyung Hee University School Of Medicine:research Institut
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Oh Seungjoon
Department Of Endocrinology And Metabolism Kyung Hee University School Of Medicine:research Institut
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Kim Young
Department Of Agricultural Chemistry The University Of Tokyo
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Woo Jeong
Department Of Endocrinology And Metabolism Kyung Hee University School Of Medicine:research Institut
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Kim Sung
Department Of Anatomy
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Kim Young
Department Of Endocrinology And Metabolism Kyung Hee University School Of Medicine:research Institut
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Kim Sung
Department Of Endocrinology And Metabolism Kyung Hee University School Of Medicine:research Institut
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Woo Jeong-taek
Department Of Endocrinology And Metabolism Kyung Hee University School Of Medicine
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Kim Sung
Department of Advanced Materials Engineering for Information and Electronics, Kyung Hee University, Yongin, Gyeonggi 446-701, Republic of Korea
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KIM Jin-Woo
Department of Biotechnology, College of Engineering, Daegu University, Gyeongbuk 712-714, Republic of Korea
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