Transient Impairment of Hippocampus-dependent Learning and Memory in Relatively Low-Dose of Acute Radiation Syndrome is Associated with Inhibition of Hippocampal Neurogenesis

スポンサーリンク

概要

• 論文の詳細を見る

• Neurogenesis in the adult hippocampus, which occurs constitutively, is vulnerable to ionizing radiation. In the relatively low-dose exposure of acute radiation syndrome (ARS), the change in the adult hippocampal function is poorly understood. This study analyzed the changes in apoptotic cell death and neurogenesis in the DGs of hippocampi from adult ICR mice with single whole-body gamma-irradiation using the TUNEL method and immunohistochemical markers of neurogenesis, Ki-67 and doublecortin (DCX). In addition, the hippocampus-dependent learning and memory tasks after single whole-body gamma-irradiation were examined in order to evaluate the hippocampus-related behavioral dysfunction in the relatively low-dose exposure of ARS. The number of TUNEL-positive apoptotic nuclei in the dentate gyrus (DG) was increased 6-12h after acute gamma-irradiation (a single dose of 0.5 to 4 Gy). In contrast, the number of Ki-67- and DCX-positive cells began to decrease significantly 6h postirradiation, reaching its lowest level 24h after irradiation. The level of Ki-67 and DCX immunoreactivity decreased in a dose-dependent manner within the range of irradiation applied (0-4 Gy). In passive avoidance and object recognition memory test, the mice trained 1 day after acute irradiation (2 Gy) showed significant memory deficits, compared with the sham controls. In conclusion, the pattern of the hippocampus-dependent memory dysfunction is consistent with the change in neurogenesis after acute irradiation. It is suggested that a relatively low dose of ARS in adult ICR mice is sufficiently detrimental to interrupt the functioning of the hippocampus, including learning and memory, possibly through the inhibition of neurogenesis.

• 日本放射線影響学会の論文
• 2008-09-16

著者

• KIM Jong

  Department of Chemical Engineering, Dong A University

• Kim Jong-choon

  Coll. Of Veterinary Medicine Chonnam National Univ.

• Kim Sung

  Department of Bioengineering and Technology, College of Engineering, Kangwon National University

• Kim Sung

  韓国

• SHIN Taekyun

  Department of Veterinary Medicine, Graduate School, Cheju National University

• MOON Changjong

  Department of Veterinary Medicine, College of Applied Life Science and Applied Radiological Science

• Lee Hae-june

  Department Of Veterinary Anatomy College Of Veterinary Medicine Chonnam National University

• Kim Jong

  Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University

• Kim Sung

  Department Of Anatomy

• KIM Joong-Sun

  Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Cen

• KANG Seong

  Department of Veterinary Surgery, College of Veterinary Medicine and Veterinary Medical Research Cen

• BAE Chun-Sik

  Department of Veterinary Surgery, College of Veterinary Medicine and Veterinary Medical Research Cen

• JIN Jae-Kwang

  Ilsong Institute of Life Science, Hallym University

• WANG Hongbing

  Department of Physiology and Neuroscience Program, Michigan State University

• Kim Seungjoon

  Department Of Veterinary Anatomy College Of Veterinary Medicine Chonnam National University

• Bae Chun-sik

  Department Of Veterinary Surgery College Of Veterinary Medicine Chonnam National University

• Jin Jae-kwang

  Ilsong Institute Of Life Science Hallym University

• Wang Hongbing

  Department Of Physiology And Neuroscience Program Michigan State University

• Sim Ki

  Department Of Neurosurgery College Of Medicine Cheju National University

• Kang Seong

  Department Of Veterinary Surgery College Of Veterinary Medicine Chonnam National University

• Kang Seong

  Department Of Chemistry And Research Institute Of Physics And Chemistry (rinpac) Chonbuk National Un

• Shin Taekyun

  Jeju National Univ. Jeju

• Shin Taekyun

  Department Of Veterinary Medicine Cheju National University

• Moon C

  Department Of Veterinary Anatomy College Of Veterinary Medicine Chonnam National University

• Moon Changjong

  Department Of Physiology University Of The Ryukyus School Of Medicine:department Of Veterinary Medic

• Shin T

  Jeju National Univ. Jeju

• Kim Jong

  Department Of Agricultural Bio-resources National Academy Of Agricultural Science Rural Development

• Shin Taekyun

  Department of Veterinary Anatomy, College of Veterinary Medicine and Research Institute for Subtropical Agriculture and Biotechnology, Cheju National University

• Lee Hae-June

  Department of Electrical Engineering, Pusan National University, Geumjeong-gu, Busan 609-735, Korea

• Kang Seong

  Department of Advanced Materials Engineering for Information and Electronics, Kyung Hee University, Yongin, Gyeonggi 446-701, Republic of Korea

• Kim Sung

  Department of Advanced Materials Engineering for Information and Electronics, Kyung Hee University, Yongin, Gyeonggi 446-701, Republic of Korea

• SHIN Taekyun

  Department of Veterinary Anatomy, College of Veterinary Medicine and Applied Radiological Science Research Institute, Jeju National University

関連論文

• Ibuprofen Racemate Separation by Simulated Moving Bed
• Preparation and characterization of nickel-chrome alloy coated by SiC (第6回資源リサイクル・材料科学に関する日韓国際シンポジウム特集号)
• IS-57 Changes of Lipid Peroxidation and Protein Oxidation incubated by Antibiotics in the Maternal Venous Plasma of Preterm Labor with Intact Amniotic Membranes and Preterm Premature Rupture of Membranes(Group8 Perinatology1,International Session)
• ISO-9 Changes of Lipid Peroxidation and Protein Oxidation after Treatment of Amoxacillin and Erythromycin, 3rd cephalosporin & Metronidazole in the Maternal Venous Plasma of Preterm Premature Rupture of Membranes(Group2 Perinatology/Reproduction/Women's H
• ゲニステインとエストラジオールが生殖器の発達に及ぼす影響 : 大豆ベースの餌によって飼育した母マウスから生まれたオスの性成熟への影響(毒性学)
• 韓国における小児市中急性呼吸器感染症から分離した肺炎球菌に対するセフジトレンおよびその他の経口抗生物質の抗菌力
• A New High-Spin Isomer in ^Sm
• L-Trp and L-Leu-OEt Derivatives of the Monascus Pigment Exert High Anti-Obesity Effects on Mice
• Inhibition of Coagulation Activation and Inflammation by a Novel Factor Xa Inhibitor Synthesized from the Earthworm Eisenia andrei(Pharmacology)
• Puerariafuran, a New Inhibitor of Advanced Glycation End Products (AGEs) Isolated from the Roots of Pueraria lobata
• 急性の実験的精巣捻転ラットにおけるAkt/Protein Kinase BとExtracellular Signal-regulated Kinaseの活性化(解剖学)
• Estimating the Parameters of the Mixture of Proportional Hazards Models with Three Types of Data
• Effects of Renin-Angiotensin System Inhibitors on the Occurrence of Acute Kidney Injury Following Off-Pump Coronary Artery Bypass Grafting
• A Stochastic Approach to Monoenergetic Space-Time Nuclear Reactor Kinetics
• Numerical Investigation of Dynamic Fluctuations Following Nuclear Reactor Transients Using a Simplified Stochastic Model
• Comparative evaluation of segmentation methods for bronchial tree in the lung parenchyma
• Classification of urinary stone and vascular calcification in noncontrast CT using morphological analysis
• Inorganic Alignment Layers Using Noncontact Method for Liquid Crystal Displays
• Ion-Beam Induced Liquid Crystal Alignment on Diamond-like Carbon and Fluorinated Diamond-like Carbon Thin Films
• Electrical Conduction Behavior of Layered Perovskite La_Ba_GaO_
• Molecular Dynamics Simulation of Collapsing Phase for a Sonoluminescing Gas Bubble in Sulfuric Acid Solutions : A Comparative Study with Theoretical Results(Atomic and molecular physics)
• Fluorescent Calix[4]arene-appended Silica Nanotubes as Selective Chemosensor and Adsorbent for Pb^ Ion
• Clinical and Radiological Prognostic Factors of Anaplastic Oligodendroglioma Treated by Combined Therapy
• Optimal Selection of Operating Point for Hessian-based Polyp Detection Method in CT Colonography
• A Cytogenetic Study of Korean Native Goat Bred in the Nuclear Power Plant using the Micronucleus Assay
• Acquisition and Modeling of Driving Skills by Using Three Dimensional Driving Simulator(Intelligent Transport System)
• Microstructural Evolution of Joint Interface between Eutectic 80Au-20Sn Solder and UBM
• Abnormal Grain Growth of Ni_3Sn_4 at Sn-3.5Ag/Ni Interface
• Effect of Under Bump Metallurgy and Reflows on Shear Strength and Microstructure of Joint between Cu Substrate and Sn-36Pb-2Ag Solder Alloy
• Thermodynamics-Aided Alloy Design and Evaluation of Pb-free Solders for High-Temperature Applications
• Effect of Reactive Amphiphiles on the Silicate Dispersion and Degradation Behavior of ABS/layered Silicate Nanocomposites
• Improving Accuracy of Airway Wall Thickness in MDCT Using a Deconvolution Technique : A Swine Phantom Study(International Forum on Medical Imaging in Asia 2009 (IFMIA 2009))
• Optimization of Hanyang University Plasma Focus Device as a Neutron Source
• Molecular Beam Epitaxial Growth of High-Quality InP/InGaAs/InP Heterostructure with Polycrystalline GaAs and GaP Decomposition Sources
• Genetic Similarity of Lilium brownii var. colchesteri in Japan and Korea
• Geographic Distribution and Habitat Differentiation in Diploid and Triploid Lilium lancifolium of South Korea
• Randomized Comparison of Cilostazol vs Clopidogrel After Drug-Eluting Stenting in Diabetic Patients : CIilostazol for Diabetic Patients in Drug-Eluting Stent (CIDES) Trial
• Systematic Lymphadenectomy Improves Survival in Patients with Advanced-Stage Primary Fallopian Tube Cancer
• Strongly Enhanced Phosphor Efficiency in GaInN White Light-Emitting Diodes Using Remote Phosphor Configuration and Diffuse Reflector Cup
• Simulation System Supporting Maintenance Decision for Multi-Unit System(Proceeding)
• Risedronate Directly Inhibits Osteoclast Differentiation and Inflammatory Bone Loss
• ラット雄性生殖器におけるセレン依存性ペルオキシダーゼ (phospholipid hydroperoxide glutathione peroxidase) mRNA の発現はエストラジオールとタモキシフェンの影響を受ける
• Ferroelectric Properties of Nb-Doped Bi_4 Ti-3O_ Thin Films Prepared Using Surfactant in Acid or Basic Atmosphere
• Pharmacokinetic study of orphenadrine using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
• 5-Hydroxytryptophan Acts on the Mitogen-Activated Protein Kinase Extracellular-Signal Regulated Protein Kinase Pathway to Modulate Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression in RAW 264.7 Cells(Biochemistry)
• Effect of Microstructure on Fatigue Strength of Bovine Compact Bones
• Effect of Maternal Restraint Stress on Fetal Development of ICR Mice
• Sess. 7-4 Estimating the Parameters of the Mixture of Proportional Hazards Models with Three Types of Data(信頼性・品質3学会合同シンポジウム)
• Estimating parameters of intensity function and maintenance effect with two types of data (日本信頼性学会第14回信頼性シンポジウム報文集) -- (セッション1 保全・解析〔英文〕)
• Demonstration of Fast Restorable All-Optical WDM Network (Joint Special Issue on Recent Progress in Optoelectronics and Communications)
• Demonstration of Fast Restorable All-Optical WDM Network (Joint Special Issue on Recent Progress in Optoelectronics and Communications)
• Transient Impairment of Hippocampus-dependent Learning and Memory in Relatively Low-Dose of Acute Radiation Syndrome is Associated with Inhibition of Hippocampal Neurogenesis
• 24-nor-Ursane Type Triterpenoids from the Stems of Rumex japonicus
• Energy-Aware Error Correction for QoS-Provisioning Real-Time Communications in Wireless Networks
• ZnO Nanorods Synthesized by Self-Catalytic Method of Metal in Atmospheric Microwave Plasma Torch Flame
• Pressure and Viscosity Effects on Thermal Geometrical Isomerization of Oxacarbocyanine Cations
• The First Unequivocal Observation of Dynamic Solvent Effects in the Thermal Geometrical Isomerization of 3, 3' - Diethyloxadicarbocyanine Iodide (DODCI)
• P-IS-26 Proportion of peripheral blood CD4+CD25high regulatory T cells in patients with gynecologic cancers(Oncology 7,Group 94,International Session)
• Comparative study of laparoscopic radical hysterectomy and radical abdominal hysterectomy in patients with FIGO stage IB cervical cancer(Oncology 9)
• Identification and characterization of potential serum marker, Haptoglobin-α and -β subunits, in ovarian cancer(Oncology 3)
• Crystallization and Characterization of Sarcosine Oxidase from Alcaligenes denitrificans subsp. denitrificans(Biological Chemistry)
• Sarcosine Oxidase Involved in Creatinine Degradation in Alcaligenes denitrificans subsp. denitrificans J9 and Arthrobacter spp. J5 and J11(Microbiology & Fermentaion Industry)
• Evaluation of Genotoxity with Various Crude Drugs(Mutagenicity, Proceedings of the 32nd Annual Meeting)
• ORAL SINGLE- AND REPEATED-DOSE TOXICITY STUDIES ON GERANTI BIO-GE YEAST^[○!R], ORGANIC GERMANIUM FORTIFIED YEASTS, IN DOGS
• ORAL SINGLE- AND REPEATED-DOSE TOXICITY STUDIES ON GERANTI BIO-GE YEAST^[○!R], ORGANIC GERMANIUM FORTIFIED YEASTS, IN RATS
• Angiographic Prevalence and Clinical Predictors of Severely Tortuous Right Subclavian Artery in Patients Undergoing Transradial Coronary Angiography and Interventions
• IS-85 The role of mechanical stretch and inflammation in cervical ripening with Foley catheter balloon(Group11 Perinatology3,International Session)
• IS-86 Changes of antioxidant levels in the uterine venous plasma, amniotic fluid, and chorioamnion after maternal supplementation vitamin C and vitamin E(Group11 Perinatology3,International Session)
• Triplet pregnancy with partial hydatidiform mole coexisting with two fetuses : A case report
• 1 PPAR-Gamma Modulates Allergic Inflammation Through Upregulation of PTEN(I. Molecular Pathogenesis of Allergic Diseases)
• Effects of Renin-Angiotensin System Inhibitors on the Occurrence of Acute Kidney Injury Following Off-Pump Coronary Artery Bypass Grafting
• A Correlation between Antioxidant Activity and Metabolite Release during the Blanching of Chrysanthemum coronarium L.
• Pyogenic Spondylitis in an S1-S2 Immobile Segment
• IV B14 Epilepsy surgery in dysembryoplastic neuroepithelial tumor
• Fossil woods from Janggi Group (Early Miocene) in Pohang Basin, Korea
• Diverse Clinical Applications Using Advantages of Allogeneic Peripheral Blood Stem Cell Transplantation
• Tumor Volume Change during Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer : Predictive Value of Recurrence(Oncology 9)
• Angioplasty of Middle Cerebral Artery Stenosis Improves Recurrent Hemichorea Caused by Basal Ganglia Hypoperfusion
• Small-Molecule Fluorescent Chemosensors for Hg^ Ion
• Gamma-Ray Susceptibility of Immature and Mature Hippocampal Cultured Cells
• Analysis of Cell Configuration Effects on Nuclear Characteristics in a Lead-Bismuth Cooled Core for TRU Incineration
• Thermal Quark Model of p^^-p Annihilation at Low Energies : Particles and Fields
• Subacute Toxicity and Toxicokinetics of a New Antibiotic, DW-224a, after Single and 4-Week Repeated Oral Administration in Dogs
• A Finite Element Analysis for Near-net-shape Forming of Aluminum Alloy Powder Under Warm Pressing
• ENGINEERING A DNA VACCINE FOR HIV-1
• Evaluation of Two Load-Balancing Primary-Backup Process Allocation Schemes
• Determination of iohexol clearance by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
• State of the Art on Research, Development and Application of Membranes in Korea
• IS-53 Evaluation of length, volume and gray-scale histogram of the cervix as predictors of successful induction(Group7 Perinatology1,International Session)
• IS-52 Umbilical venous interleukin-6, lipid peroxide, and protein carbonyl levels in preterm birth(Group7 Perinatology1,International Session)
• IS-51 Predictive value of serum interlukin-6, C-reactive protein, lipid peroxide, and amniotic fluid index to duration of the latent period in preterm premature rupture of membranes(Group7 Perinatology1,International Session)
• IS-50 Maternal serum levels of C-reactive protein and placental levels of IL-6, lipid peroxide, and protein carbonyl in preterm birth according to histologic horioamnionitis(Group7 Perinatology1,International Session)
• ISO-8 Prophylaxis of Recurrent Preeclampsia : Supplementation with Low-Dose Aspirin, Calcium, and Vitamin C(Group2 Perinatology,International Session : Oral Presentation)
• Protective immune correlates can segregate by vaccine type in a murine herpes model system
• 3.1 Redundancy Optimization Using the Genetic Algorithm in a Hierarchical Modular Structure
• Chronic myeloid leukemia patient manifesting fatal hepatitis B virus reactivation during treatment with imatinib rescued by liver transplantation : case report and literature review
• Resiliency of Network Topologies under Path-Based Attacks(Internet)
• L-Trp and L-Leu-OEt Derivatives of the Monascus Pigment Exert High Anti-Obesity Effects on Mice
• Ovarian and multiple lymph nodes recurrence of acute lymphoblastic leukemia : a case report and review of literature
• Identification of endothelial cell-specific molecule-1 as a potential serum marker for colorectal cancer

もっと見る 閉じる

スポンサーリンク